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rdf:type |
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lifeskim:mentions |
umls-concept:C0011306,
umls-concept:C0017262,
umls-concept:C0020963,
umls-concept:C0021027,
umls-concept:C0039195,
umls-concept:C0205252,
umls-concept:C0205263,
umls-concept:C0205349,
umls-concept:C0332206,
umls-concept:C0487637,
umls-concept:C1171362,
umls-concept:C1515670,
umls-concept:C1539081,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C2349975
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pubmed:issue |
9
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pubmed:dateCreated |
2003-11-20
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pubmed:abstractText |
Immature dendritic cells (DCs) have the tolerogenic potential to induce alloantigen-specific immune tolerance. Cytotoxic T lymphocyte antigen 4 immunoglobulin (CTLA4Ig) gene-modified immature DCs have been shown to maintain their tolerogenicity and prolong allograft survival to some extent. We investigated whether blockade of CD40 pathway by anti-CD40 ligand (L) monoclonal antibody (mAb) could enhance the immune tolerance induction by immature DCs genetically modified to express CTLA4Ig (DC-CTLA4Ig).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0041-1337
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1351-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14627915-Animals,
pubmed-meshheading:14627915-Antigens, CD40,
pubmed-meshheading:14627915-Base Sequence,
pubmed-meshheading:14627915-Bone Marrow Cells,
pubmed-meshheading:14627915-CD40 Ligand,
pubmed-meshheading:14627915-Cell Differentiation,
pubmed-meshheading:14627915-Cytotoxicity, Immunologic,
pubmed-meshheading:14627915-DNA Primers,
pubmed-meshheading:14627915-Dendritic Cells,
pubmed-meshheading:14627915-Graft Survival,
pubmed-meshheading:14627915-Hematopoietic Stem Cells,
pubmed-meshheading:14627915-Histocompatibility Antigens Class II,
pubmed-meshheading:14627915-Immunoconjugates,
pubmed-meshheading:14627915-Immunosuppression,
pubmed-meshheading:14627915-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:14627915-Lymphocytes,
pubmed-meshheading:14627915-Mice,
pubmed-meshheading:14627915-Mice, Inbred BALB C,
pubmed-meshheading:14627915-Mice, Inbred C3H,
pubmed-meshheading:14627915-Mice, Inbred C57BL,
pubmed-meshheading:14627915-Polymerase Chain Reaction,
pubmed-meshheading:14627915-Spleen,
pubmed-meshheading:14627915-T-Lymphocytes,
pubmed-meshheading:14627915-Transfection,
pubmed-meshheading:14627915-Transplantation, Homologous
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pubmed:year |
2003
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pubmed:articleTitle |
Blockade of CD40 pathway enhances the induction of immune tolerance by immature dendritic cells genetically modified to express cytotoxic T lymphocyte antigen 4 immunoglobulin.
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pubmed:affiliation |
Institute of Immunology, Zhejiang University, Hangzhou, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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