|
pubmed:abstractText |
A relationship between free fatty acids, intramuscular triglycerides (TG(M)s), and insulin resistance is widely accepted. The intracellular level of malonyl-coenzyme A (CoA) was suggested to be the possible link. Acetyl-CoA carboxylase (ACC) is a key enzyme in fatty acid metabolism, catalyzing the synthesis of malonyl-CoA, a fatty acid acyl-chain elongation unit, from acetyl-CoA. We assessed ACC2 mRNA expression variations in skeletal muscle of subjects who have undergone biliopancreatic diversion (BPD) operation. BPD, in fact inducing a massive lipid malabsorption, leads to a reversion of insulin resistance.
|
|
pubmed:affiliation |
Department of Internal Medicine, Consiglio Nazionale delle Richerche (CNR) Center, Catholic University of the Sacred Heart, Largo A. Gemelli 8, 00168 Rome, Italy. giusi_rosa@hotmail.com
|
