Linked Life Data

14624503

Source:http://linkedlifedata.com/resource/pubmed/id/14624503

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-11-18
pubmed:abstractText
It has been a great challenge to make the thickness of engineered cartilage adjustable to cover the range of both partial-thickness and full-thickness articular cartilage defects. We developed a novel kind of composite web scaffold that could be used for tissue enginnering of articular cartilage with the thickness adjustable between 200 microm and 8 mm. The composite web showed a unique structure having web-like collagen microsponges formed in the openings of a mechanically strong knitted mesh of poly(lactic-co-glycolic acid). The knitted mesh served as a skeleton reinforcing the composite web, while the web-like collagen microsponges facilitated cell seeding, cell distribution, and tissue formation. Bovine chondrocytes cultured in the composite web showed a spatially even distribution, maintained their natural morphology, and produced cartilaginous extracellular matrices such as type II collagen and aggrecan. The thickness of the implant can be simply adjusted by laminating or rolling the web sheets. Not only did the histological structure of the engineered cartilage patches match the bovine native articular cartilage, but also their dynamic complex modulus, structural stiffness, and phase lag reached 37.8, 57.0, and 86.3% of those of native bovine articular cartilage, respectively. The composite web could be an important scaffold for tissue engineering.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1549-3296
pubmed:author
pubmed:copyrightInfo
Copyright 2003 Wiley Periodicals, Inc. J Biomed Mater Res 67A: 1170-1180, 2003
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1170-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:14624503-Aggrecans, pubmed-meshheading:14624503-Animals, pubmed-meshheading:14624503-Biocompatible Materials, pubmed-meshheading:14624503-Cartilage, Articular, pubmed-meshheading:14624503-Cattle, pubmed-meshheading:14624503-Cells, Cultured, pubmed-meshheading:14624503-Chondrocytes, pubmed-meshheading:14624503-Collagen Type I, pubmed-meshheading:14624503-Collagen Type II, pubmed-meshheading:14624503-Extracellular Matrix Proteins, pubmed-meshheading:14624503-Lactic Acid, pubmed-meshheading:14624503-Lectins, C-Type, pubmed-meshheading:14624503-Materials Testing, pubmed-meshheading:14624503-Microscopy, Electron, Scanning, pubmed-meshheading:14624503-Polyglycolic Acid, pubmed-meshheading:14624503-Polymers, pubmed-meshheading:14624503-Proteoglycans, pubmed-meshheading:14624503-Tensile Strength, pubmed-meshheading:14624503-Tissue Engineering
pubmed:year
2003
pubmed:articleTitle
The use of a novel PLGA fiber/collagen composite web as a scaffold for engineering of articular cartilage tissue with adjustable thickness.
pubmed:affiliation
Tissue Engineering Research Center, AIST Kansai, Amagasaki Site, National Institute of Advanced Industrial Science and Technology, 3-11-46 Nakoji, Amagasaki, Hyogo 661-0974, Japan. gouping-chen@aist.go.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't