Linked Life Data

14624487

Source:http://linkedlifedata.com/resource/pubmed/id/14624487

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-11-19
pubmed:abstractText
The nucleus rotundus is the largest nucleus of the avian thalamus. It is an important center of visual information processing and conveys information from the optic tectum to the ectostriatum in the telencephalon. The nucleus rotundus is generally believed to contain internal divisions processing information on color, form, motion, and looming of visual objects. The detailed arrangement of these internal divisions is unclear. Here, we map the expression of four classic cadherins (N-cadherin, R-cadherin, cadherin-6B, and cadherin-7), which are markers for specific functional gray matter divisions and their fiber connections in the vertebrate brain. Results show that each cadherin is expressed by one coherent part of the nucleus rotundus that is connected to other brain structures by fiber tracts expressing the same subtype of cadherin. Overall, the expression of the four cadherins encompasses almost the entire nucleus rotundus. The four cadherin-expressing parts show different degrees of overlap. For example, the cadherin-6B part and the cadherin-7 part overlap extensively, whereas the R-cadherin part and the cadherin-6B part show little overlap and are partially complementary. Regions with shallow gradients of cadherin expression alternate with regions that show relatively abrupt changes in cadherin expression. At some points, changes of cadherin expression are also arranged in a pinwheel-like fashion, alternating between clockwise and counterclockwise orientations. In general, these results are reminiscent of the organization of functional modules in the mammalian visual cortex. It is speculated that each domain of cadherin expression corresponds to a functional domain, which processes a specific stimulus feature.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0021-9967
pubmed:author
pubmed:copyrightInfo
Copyright 2003 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
467
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
536-48
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Internal structure of the nucleus rotundus revealed by mapping cadherin expression in the embryonic chicken visual system.
pubmed:affiliation
Institute of Anatomy, University of Duisburg-Essen School of Medicine, D-45122 Essen, Germany.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't