| pubmed-article:14623871 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14623871 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:14623871 | lifeskim:mentions | umls-concept:C0042172 | lld:lifeskim |
| pubmed-article:14623871 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:14623871 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:14623871 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:14623871 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:14623871 | lifeskim:mentions | umls-concept:C0019868 | lld:lifeskim |
| pubmed-article:14623871 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:14623871 | lifeskim:mentions | umls-concept:C1370600 | lld:lifeskim |
| pubmed-article:14623871 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:14623871 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:14623871 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:14623871 | lifeskim:mentions | umls-concept:C0324024 | lld:lifeskim |
| pubmed-article:14623871 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:14623871 | pubmed:dateCreated | 2003-11-25 | lld:pubmed |
| pubmed-article:14623871 | pubmed:abstractText | Transcriptional repression of E-cadherin, characteristic of epithelial to mesenchymal transition, is often found also during tumor cell invasion. At metastases, migratory fibroblasts sometimes revert to an epithelial phenotype, by a process involving regulation of the E-cadherin-beta-catenin complex. We investigated the molecular basis of this regulation, using human colon cancer cells with aberrantly activated beta-catenin signaling. Sparse cultures mimicked invasive tumor cells, displaying low levels of E-cadherin due to transcriptional repression of E-cadherin by Slug. Slug was induced by beta-catenin signaling and, independently, by ERK. Dense cultures resembled a differentiated epithelium with high levels of E-cadherin and beta-catenin in adherens junctions. In such cells, beta-catenin signaling, ErbB-1/2 levels, and ERK activation were reduced and Slug was undetectable. Disruption of E-cadherin-mediated contacts resulted in nuclear localization and signaling by beta-catenin, induction of Slug and inhibition of E-cadherin transcription, without changes in ErbB-1/2 and ERK activation. This autoregulation of E-cadherin by cell-cell adhesion involving Slug, beta-catenin and ERK could be important in tumorigenesis. | lld:pubmed |
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| pubmed-article:14623871 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14623871 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14623871 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14623871 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14623871 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14623871 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:14623871 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:14623871 | pubmed:author | pubmed-author:Conacci-Sorre... | lld:pubmed |
| pubmed-article:14623871 | pubmed:author | pubmed-author:Ben-Ze'evAvri... | lld:pubmed |
| pubmed-article:14623871 | pubmed:author | pubmed-author:Ben-YedidiaTa... | lld:pubmed |
| pubmed-article:14623871 | pubmed:author | pubmed-author:SavagnerPierr... | lld:pubmed |
| pubmed-article:14623871 | pubmed:author | pubmed-author:SimchaInbalI | lld:pubmed |
| pubmed-article:14623871 | pubmed:author | pubmed-author:BlechmanJanna... | lld:pubmed |
| pubmed-article:14623871 | pubmed:issnType | Print | lld:pubmed |
