| pubmed-article:14623342 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14623342 | lifeskim:mentions | umls-concept:C0281361 | lld:lifeskim |
| pubmed-article:14623342 | lifeskim:mentions | umls-concept:C0059239 | lld:lifeskim |
| pubmed-article:14623342 | lifeskim:mentions | umls-concept:C1565434 | lld:lifeskim |
| pubmed-article:14623342 | lifeskim:mentions | umls-concept:C2347610 | lld:lifeskim |
| pubmed-article:14623342 | lifeskim:mentions | umls-concept:C0045093 | lld:lifeskim |
| pubmed-article:14623342 | lifeskim:mentions | umls-concept:C1136031 | lld:lifeskim |
| pubmed-article:14623342 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:14623342 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:14623342 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:14623342 | pubmed:dateCreated | 2003-11-18 | lld:pubmed |
| pubmed-article:14623342 | pubmed:abstractText | Focal adhesion kinase (FAK) is an important regulator of cellular signaling, migration, apoptosis, and cell cycle progression. We tested the hypothesis that FAK is a determinant of gemcitabine chemoresistance in pancreatic adenocarcinoma cells and examined the effect of inhibiting FAK expression on gemcitabine-induced cytotoxicity in vitro and in vivo. FAK expression was quantified by Western and Northern blots. Expression of FAK was suppressed using small interfering RNA (siRNA). Gemcitabine-induced cytotoxicity was quantified and apoptosis was characterized. Akt activity was determined by in vitro kinase assay. We assessed the therapeutic applicability of FAK siRNA in a nude mouse orthotopic xenograft model. While not affecting cellular proliferation or apoptosis in the absence of gemcitabine, FAK siRNA potentiated gemcitabine-induced cytotoxicity in vitro and in vivo. FAK siRNA treatment suppressed Akt activity, which may contribute to its chemosensitizing effect. | lld:pubmed |
| pubmed-article:14623342 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14623342 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14623342 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14623342 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14623342 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:14623342 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:14623342 | pubmed:author | pubmed-author:AshleyStanley... | lld:pubmed |
| pubmed-article:14623342 | pubmed:author | pubmed-author:ZinnerMichael... | lld:pubmed |
| pubmed-article:14623342 | pubmed:author | pubmed-author:WhangEdward... | lld:pubmed |
| pubmed-article:14623342 | pubmed:author | pubmed-author:ItoHiromichiH | lld:pubmed |
| pubmed-article:14623342 | pubmed:author | pubmed-author:DuxburyMark... | lld:pubmed |
| pubmed-article:14623342 | pubmed:author | pubmed-author:BenoitEricE | lld:pubmed |
| pubmed-article:14623342 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14623342 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:14623342 | pubmed:volume | 311 | lld:pubmed |
| pubmed-article:14623342 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14623342 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14623342 | pubmed:pagination | 786-92 | lld:pubmed |
| pubmed-article:14623342 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:14623342 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14623342 | pubmed:articleTitle | RNA interference targeting focal adhesion kinase enhances pancreatic adenocarcinoma gemcitabine chemosensitivity. | lld:pubmed |
| pubmed-article:14623342 | pubmed:affiliation | Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:14623342 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14623342 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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