Linked Life Data

14623236

Source:http://linkedlifedata.com/resource/pubmed/id/14623236

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-11-18
pubmed:abstractText
Leg development in Drosophila has been studied in much detail. However, Drosophila limbs form in the larva as imaginal discs and not during embryogenesis as in most other arthropods. Here, we analyze appendage genes in the spider Cupiennius salei and the beetle Tribolium castaneum. Differences in decapentaplegic (dpp) expression suggest a different mode of distal morphogen signaling suitable for the specific geometry of growing limb buds. Also, expression of the proximal genes homothorax (hth) and extradenticle (exd) is significantly altered: in the spider, exd is restricted to the proximal leg and hth expression extends distally, while in insects, exd is expressed in the entire leg and hth is restricted to proximal parts. This reversal of spatial specificity demonstrates an evolutionary shift, which is nevertheless compatible with a conserved role of this gene pair as instructor of proximal fate. Different expression dynamics of dachshund and Distal-less point to modifications in the regulation of the leg gap gene system. We comment on the significance of this finding for attempts to homologize leg segments in different arthropod classes. Comparison of the expression profiles of H15 and optomotor-blind to the Drosophila patterns suggests modifications also in the dorsal-ventral patterning system of the legs. Together, our results suggest alterations in many components of the leg developmental system, namely proximal-distal and dorsal-ventral patterning, and leg segmentation. Thus, the leg developmental system exhibits a propensity to evolutionary change, which probably forms the basis for the impressive diversity of arthropod leg morphologies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0012-1606
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
264
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
119-40
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:14623236-Amino Acid Sequence, pubmed-meshheading:14623236-Animals, pubmed-meshheading:14623236-Body Patterning, pubmed-meshheading:14623236-Drosophila Proteins, pubmed-meshheading:14623236-Drosophila melanogaster, pubmed-meshheading:14623236-Extremities, pubmed-meshheading:14623236-Gene Expression Regulation, Developmental, pubmed-meshheading:14623236-Homeodomain Proteins, pubmed-meshheading:14623236-In Situ Hybridization, pubmed-meshheading:14623236-Molecular Sequence Data, pubmed-meshheading:14623236-Morphogenesis, pubmed-meshheading:14623236-Nuclear Proteins, pubmed-meshheading:14623236-Phylogeny, pubmed-meshheading:14623236-Proto-Oncogene Proteins, pubmed-meshheading:14623236-Sequence Alignment, pubmed-meshheading:14623236-Spiders, pubmed-meshheading:14623236-T-Box Domain Proteins, pubmed-meshheading:14623236-Tribolium, pubmed-meshheading:14623236-Wnt1 Protein
pubmed:year
2003
pubmed:articleTitle
Gene expression in spider appendages reveals reversal of exd/hth spatial specificity, altered leg gap gene dynamics, and suggests divergent distal morphogen signaling.
pubmed:affiliation
Institut für Genetik, Universität zu Köln, Weyertal 121, D-50931 Köln, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't