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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2003-11-18
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pubmed:abstractText |
The oxazolidinones are promising agents for the treatment of infections caused by gram-positive bacteria, including multidrug-resistant strains. In ongoing studies we have discovered that a strategically placed chiral center of appropriate absolute configuration improves the antibacterial activity of indolinyl oxazolidinone analogues (gram-positive MIC's<0.5 microg/mL for the most potent congeners). The design, synthesis, antibacterial activity and pharmacokinetic profile of a selected series of alpha-methylated indoline derivatives and a related set of tetrahydroquinolyl and dihydrobenzoxazinyl analogues are discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:AdamsWade JWJ,
pubmed-author:BarbachynMichael RMR,
pubmed-author:CiskeFred LFL,
pubmed-author:DolakLester ALA,
pubmed-author:FordCharles WCW,
pubmed-author:FriisJanice MJM,
pubmed-author:GeninMichael JMJ,
pubmed-author:GregaKevin CKC,
pubmed-author:LeeChi SingCS,
pubmed-author:SeestEric PEP,
pubmed-author:WattWilliamW,
pubmed-author:ZurenkoGary EGE
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4235-9
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pubmed:meshHeading |
pubmed-meshheading:14623008-Anti-Bacterial Agents,
pubmed-meshheading:14623008-Drug Design,
pubmed-meshheading:14623008-Drug Resistance, Bacterial,
pubmed-meshheading:14623008-Gram-Negative Bacteria,
pubmed-meshheading:14623008-Gram-Positive Bacteria,
pubmed-meshheading:14623008-Hydroquinones,
pubmed-meshheading:14623008-Indoles,
pubmed-meshheading:14623008-Microbial Sensitivity Tests,
pubmed-meshheading:14623008-Oxazines,
pubmed-meshheading:14623008-Oxazolidinones,
pubmed-meshheading:14623008-Structure-Activity Relationship
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pubmed:year |
2003
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pubmed:articleTitle |
The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones.
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pubmed:affiliation |
Pfizer, 7000 Portage Road, Kalamazoo, MI 49001, USA.
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pubmed:publicationType |
Journal Article
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