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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2003-11-18
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pubmed:abstractText |
Antimicrobial compounds incorporating oxazolidinone and quinolone pharmacophore substructures have been synthesized and evaluated. Representative analogues 2, 5, and 6 display an improved potency versus linezolid against gram-positive and fastidious gram-negative pathogens. The compounds are also active against linezolid- and ciprofloxacin-resistant Staphylococcus aureus and Enterococcus faecium strains. The MOA for these new antimicrobials is consistent with a combination of protein synthesis and gyrase A/topoisomerase IV inhibition, with a structure-dependent degree of the contribution from each inhibitory mechanism.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BanittLee SLS,
pubmed-author:BarbachynMichael RMR,
pubmed-author:EvansJonathan MJM,
pubmed-author:GageJames RJR,
pubmed-author:GomezMarcelaM,
pubmed-author:GordeevMikhail FMF,
pubmed-author:HackbarthCorinneC,
pubmed-author:LuehrGary WGW,
pubmed-author:MorinSara ESE,
pubmed-author:ParkerChristian NCN,
pubmed-author:PatelDinesh VDV,
pubmed-author:TriasJoaquimJ,
pubmed-author:WhiteRichard JRJ,
pubmed-author:ZurenkoGary EGE
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4213-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14623004-Acetamides,
pubmed-meshheading:14623004-Anti-Bacterial Agents,
pubmed-meshheading:14623004-Ciprofloxacin,
pubmed-meshheading:14623004-DNA Topoisomerase IV,
pubmed-meshheading:14623004-Drug Resistance, Bacterial,
pubmed-meshheading:14623004-Gram-Negative Bacteria,
pubmed-meshheading:14623004-Gram-Positive Bacteria,
pubmed-meshheading:14623004-Microbial Sensitivity Tests,
pubmed-meshheading:14623004-Molecular Structure,
pubmed-meshheading:14623004-Oxazolidinones,
pubmed-meshheading:14623004-Quinolones,
pubmed-meshheading:14623004-Structure-Activity Relationship
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pubmed:year |
2003
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pubmed:articleTitle |
Novel oxazolidinone-quinolone hybrid antimicrobials.
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pubmed:affiliation |
Vicuron Pharmaceuticals Inc., 34790 Ardentech Ct., Fremont, CA 94555, USA. mgordeev@vicuron.com
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pubmed:publicationType |
Journal Article,
Comparative Study
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