Source:http://linkedlifedata.com/resource/pubmed/id/14622976
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2003-11-18
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pubmed:abstractText |
The aim of our study was to determine, as a function of [Cu(2+)]/[LDL] ratios (0.5 and 0.05) and of oxidation phases, the extent of LDL oxidation by assessing the lipid and apo B oxidation products. The main results showed that: (i) kinetics of conjugated diene formation presented four phases for Cu(2+)/LDL ratio of 0.5 and two phases for [Cu(2+)]/[LDL] ratio of 0.05; (ii) oxidation product formation (cholesteryl ester and phosphatidylcholine hydroperoxides, apo B carbonyl groups) occurred early in the presence of endogenous antioxidants, under both copper oxidation conditions; (iii) apo B carbonylated fragments appeared when antioxidants were totally consumed at [Cu(2+)]/[LDL] ratio of 0.5; and (iv) antioxidant concentrations were stable, oxysterol formation was negligible, and no carbonylated fragment was detected at [Cu(2+)]/[LDL] ratio of 0.05. Depending on the copper/LDL ratio, oxidized LDL differ greatly in the nature of lipid peroxidation product and the degree of apo B fragmentation.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins B,
http://linkedlifedata.com/resource/pubmed/chemical/Copper,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Tocopherol,
http://linkedlifedata.com/resource/pubmed/chemical/beta Carotene
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0003-9861
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
420
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
68-78
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14622976-Apolipoproteins B,
pubmed-meshheading:14622976-Combinatorial Chemistry Techniques,
pubmed-meshheading:14622976-Copper,
pubmed-meshheading:14622976-Humans,
pubmed-meshheading:14622976-Lipids,
pubmed-meshheading:14622976-Lipoproteins, LDL,
pubmed-meshheading:14622976-Oxidation-Reduction,
pubmed-meshheading:14622976-alpha-Tocopherol,
pubmed-meshheading:14622976-beta Carotene
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pubmed:year |
2003
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pubmed:articleTitle |
Extent of copper LDL oxidation depends on oxidation time and copper/LDL ratio: chemical characterization.
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pubmed:affiliation |
Laboratoire de Biochimie Métabolique et Clinique, Faculté de Pharmacie, 4, avenue de l'Observatoire, 75270 Paris Cedex 06, France. ptherond@ch-versailles.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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