Linked Life Data

14622944

Source:http://linkedlifedata.com/resource/pubmed/id/14622944

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2003-11-19
pubmed:abstractText
This introductory chapter tentatively draws a parallel between some of the highlights of basic aging research and their incidence for the understanding of age-associated pathologies. Some of the most important mechanisms described for cell- and tissue-aging, such as limited cell-proliferation, "parasitic" reactions, such as non-enzymatic glycation, ROS-production, uncontrolled proteolysis involving matricryptic sites, receptor loss and uncoupling appear to be the most promising links between those two approaches to fundamental and clinical gerontology. Some of the "parasitic", epigenetic, post-translational reactions lead to vicious circles which over the years might well produce cell- and tissue-damage as seen in most age-associated diseases. There is little doubt that the better understanding of these relationships will also prove helpful for pharmacological research as related to the age-associated pathologies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0369-8114
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
543-9
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Aging, from basic research to pathological applications.
pubmed:affiliation
Laboratoire de Recherche Ophtalmologique, Université Paris 6, Hôpital Hôtel Dieu, 1, place du Parvis-Notre-Dame, 75181 Paris 4, France. lrobert1@compuserve.com
pubmed:publicationType
Journal Article, Review