Linked Life Data

14622421

Source:http://linkedlifedata.com/resource/pubmed/id/14622421

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-11-19
pubmed:abstractText
In this paper we show that RNase R is a cold shock protein that is induced seven- to eightfold by cold shock and that its expression is tightly regulated by temperature. Transcriptional studies reveal that the rnr gene is co-transcribed with flanking genes as an operon induced under cold shock. The induction of RNase R levels is mainly a result of the stabilization of the rnr transcripts. The transient stability of the rnr transcripts is shown to be regulated by PNPase at the end of the acclimation phase. Studies with an rnr mutant revealed a cold-shock phenotype showing that RNase R contributes to growth at low temperatures. We have shown that RNase R can be involved in the maturation of SsrA/tmRNA, an important small stable RNA involved in protein tagging and ribosome rescue. The wide biological significance of RNase R regarding adaptation to cold shock and its involvement in RNA surveillance, protein quality control and pathogenesis is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0950-382X
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1349-60
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:14622421-Bacterial Proteins, pubmed-meshheading:14622421-Base Sequence, pubmed-meshheading:14622421-Cold Temperature, pubmed-meshheading:14622421-Enzyme Induction, pubmed-meshheading:14622421-Escherichia coli, pubmed-meshheading:14622421-Escherichia coli Proteins, pubmed-meshheading:14622421-Exoribonucleases, pubmed-meshheading:14622421-Molecular Sequence Data, pubmed-meshheading:14622421-Operon, pubmed-meshheading:14622421-Phenotype, pubmed-meshheading:14622421-Polyribonucleotide Nucleotidyltransferase, pubmed-meshheading:14622421-RNA, Bacterial, pubmed-meshheading:14622421-RNA, Messenger, pubmed-meshheading:14622421-RNA, Transfer, pubmed-meshheading:14622421-RNA Processing, Post-Transcriptional, pubmed-meshheading:14622421-RNA Stability, pubmed-meshheading:14622421-Transcription, Genetic
pubmed:year
2003
pubmed:articleTitle
Cold shock induction of RNase R and its role in the maturation of the quality control mediator SsrA/tmRNA.
pubmed:affiliation
Instituto Tecnologia Química e Biológica, Universidade Nova de Lisboa, Apt 127, 2781-901 Oeiras, Portugal.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't