Source:http://linkedlifedata.com/resource/pubmed/id/14621912
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
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| pubmed:dateCreated |
2003-11-18
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| pubmed:abstractText |
We analyzed the expression of class II antigens on graft tubular cells and the expression of IL-2R on lymphoid cells in 314 prospective aspiration biopsies taken from 30 consecutive patients with histologically verified acute vascular rejection (AVR). Based on histology, two main groups were seen: 11 grafts had features of AVR only and 19 grafts had a combination of AVR and acute cellular rejection (ACR). The AVR findings were also predominant in the latter group. In the grafts with a combination of AVR and ACR, patterns similar to ordinary ACR were seen in class II and IL-2R expression. On the contrary, no class II or IL-2R induction could be seen in the grafts with pure AVR and irreversible rejection. This pattern, demonstrated by immunocytology, suggested that AVR is a heterogenous group of rejections, where different cellular and molecular mechanisms are operating. Humoral mechanisms might be involved in these rejections.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0934-0874
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
5 Suppl 1
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
S690-1
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:14621912-Acute Disease,
pubmed-meshheading:14621912-Biological Markers,
pubmed-meshheading:14621912-Biopsy, Needle,
pubmed-meshheading:14621912-Graft Rejection,
pubmed-meshheading:14621912-HLA-DR Antigens,
pubmed-meshheading:14621912-Humans,
pubmed-meshheading:14621912-Kidney Transplantation,
pubmed-meshheading:14621912-Postoperative Period,
pubmed-meshheading:14621912-Receptors, Interleukin-2,
pubmed-meshheading:14621912-Renal Circulation,
pubmed-meshheading:14621912-Time Factors,
pubmed-meshheading:14621912-Transplantation, Homologous
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| pubmed:year |
1992
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| pubmed:articleTitle |
Expression of activation markers, HLA class II and IL-2R in acute vascular rejection of human renal allografts.
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| pubmed:affiliation |
Transplantation Laboratory, University of Helsinki, Helsinki, Finland.
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| pubmed:publicationType |
Journal Article
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