|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2003-11-17
|
|
pubmed:abstractText |
7,12-dimethylbenz [a] anthracene (DMBA) administration to pubertal rats causes breast tumors and inhibits glutathione (GSH) production. Our previous results have established that oral glutamine (GLN) supplementation significantly reduced tumor development, restored the depressed GSH production, and caused a significant decrease in the circulating levels of insulinlike growth factor-1 (IGF-1). The present study was designed to investigate the involvement of the IGF-1-activated phosphatidylinositol 3 kinase (PI-3K)/Akt apoptotic signaling pathway.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/9,10-Dimethyl-1,2-benzanthracene,
http://linkedlifedata.com/resource/pubmed/chemical/Akt1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamine,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Somatomedin
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0148-6071
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
27
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
404-10
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:14621121-9,10-Dimethyl-1,2-benzanthracene,
pubmed-meshheading:14621121-Adenocarcinoma,
pubmed-meshheading:14621121-Administration, Oral,
pubmed-meshheading:14621121-Animals,
pubmed-meshheading:14621121-Apoptosis,
pubmed-meshheading:14621121-Biological Markers,
pubmed-meshheading:14621121-Breast Neoplasms,
pubmed-meshheading:14621121-Carcinogens,
pubmed-meshheading:14621121-Disease Models, Animal,
pubmed-meshheading:14621121-Down-Regulation,
pubmed-meshheading:14621121-Female,
pubmed-meshheading:14621121-Glutamine,
pubmed-meshheading:14621121-Glutathione,
pubmed-meshheading:14621121-Insulin-Like Growth Factor I,
pubmed-meshheading:14621121-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:14621121-Protein-Serine-Threonine Kinases,
pubmed-meshheading:14621121-Proto-Oncogene Proteins,
pubmed-meshheading:14621121-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:14621121-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:14621121-Rats,
pubmed-meshheading:14621121-Rats, Sprague-Dawley,
pubmed-meshheading:14621121-Receptors, Somatomedin,
pubmed-meshheading:14621121-Signal Transduction,
pubmed-meshheading:14621121-Up-Regulation,
pubmed-meshheading:14621121-Women's Health
|
|
pubmed:articleTitle |
Oral glutamine (AES-14) supplementation inhibits PI-3k/Akt signaling in experimental breast cancer.
|
|
pubmed:affiliation |
Division of Breast Surgical Oncology, University of Arkansas for Medical Sciences, Little Rock, Arsansas 72205, USA.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study
|
