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rdf:type |
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lifeskim:mentions |
umls-concept:C0017797,
umls-concept:C0017817,
umls-concept:C0025519,
umls-concept:C0027061,
umls-concept:C0035126,
umls-concept:C0178602,
umls-concept:C0205171,
umls-concept:C0332161,
umls-concept:C0456205,
umls-concept:C0542341,
umls-concept:C1522564,
umls-concept:C1550605,
umls-concept:C2349975
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pubmed:issue |
6
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|
pubmed:dateCreated |
2003-11-17
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pubmed:abstractText |
Myocardial ischemia and reperfusion (I/R) injury causes significant morbidity and mortality. Protection against I/R injury may occur via preservation of tissue metabolism and ATP content, preservation of reduced glutathione, and stimulation of heat shock protein (HSP) synthesis. Supplementation with glutamine (GLN) has been reported to have beneficial effects on all of these protective pathways. Thus, we hypothesized that GLN pretreatment given to the rat in vivo would protect the myocardium against I/R-induced dysfunction.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0148-6071
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
396-403
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pubmed:dateRevised |
2007-2-21
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pubmed:meshHeading |
pubmed-meshheading:14621120-Adenosine Diphosphate,
pubmed-meshheading:14621120-Adenosine Triphosphate,
pubmed-meshheading:14621120-Alanine,
pubmed-meshheading:14621120-Animals,
pubmed-meshheading:14621120-Cardiac Output,
pubmed-meshheading:14621120-Coronary Circulation,
pubmed-meshheading:14621120-Disease Models, Animal,
pubmed-meshheading:14621120-Dose-Response Relationship, Drug,
pubmed-meshheading:14621120-Glucose,
pubmed-meshheading:14621120-Glutamine,
pubmed-meshheading:14621120-Glutathione,
pubmed-meshheading:14621120-HSP72 Heat-Shock Proteins,
pubmed-meshheading:14621120-Heart,
pubmed-meshheading:14621120-Heart Rate,
pubmed-meshheading:14621120-Heat-Shock Proteins,
pubmed-meshheading:14621120-Injections, Intravenous,
pubmed-meshheading:14621120-Lactic Acid,
pubmed-meshheading:14621120-Male,
pubmed-meshheading:14621120-Models, Cardiovascular,
pubmed-meshheading:14621120-Myocardial Reperfusion Injury,
pubmed-meshheading:14621120-Myocardium,
pubmed-meshheading:14621120-NAD,
pubmed-meshheading:14621120-Rats,
pubmed-meshheading:14621120-Rats, Sprague-Dawley,
pubmed-meshheading:14621120-Time Factors
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pubmed:articleTitle |
Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injury.
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pubmed:affiliation |
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA. paul.wischmeyer@UCHSC.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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