Source:http://linkedlifedata.com/resource/pubmed/id/14618390
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2004-1-27
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| pubmed:abstractText |
Genetic polymorphisms in the apolipoprotein B (apoB) gene have been reported to be associated with altered serum lipids and susceptibility to cholesterol gallstones (GS). Gallstones are among the well-known risk factors for carcinoma of the gallbladder (GBC). In the present study, the association between the XbaI polymorphism of the apo B gene was examined in patients with GBC and GS and in normal controls in a north Indian population. DNA samples from patients with GBC (n=153), GS (n=117) and healthy subjects (n=137) were analysed for the apoB- XbaI polymorphism by polymerase chain reaction followed by restriction fragment length polymorphism. The genotype X+/- was less frequent in patients with GBC (39.2%) than in those with GS (68.3%) and in normal subjects (66.4%; P<0.00001). In contrast, there was an increase in the homozygous X-/- genotype in patients with GBC (54.9%) as compared with those with GS (23.9%) and normal subjects (25.5%; P<0.00001). The frequency of the X- allele was found to be significantly increased in GBC patients with or without GS (odds ratio=2.3 and 1.7, respectively). We suggest that the apoB-XbaI gene polymorphism confers susceptibility to carcinoma of the gallbladder under specific environmental conditions.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein B-100,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins B,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyribonucleases, Type II...,
http://linkedlifedata.com/resource/pubmed/chemical/endodeoxyribonuclease XBAI
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
0340-6717
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
114
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
280-3
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:14618390-Adult,
pubmed-meshheading:14618390-Aged,
pubmed-meshheading:14618390-Alleles,
pubmed-meshheading:14618390-Apolipoprotein B-100,
pubmed-meshheading:14618390-Apolipoproteins B,
pubmed-meshheading:14618390-Base Sequence,
pubmed-meshheading:14618390-Cholelithiasis,
pubmed-meshheading:14618390-Deoxyribonucleases, Type II Site-Specific,
pubmed-meshheading:14618390-Female,
pubmed-meshheading:14618390-Gallbladder Neoplasms,
pubmed-meshheading:14618390-Gene Frequency,
pubmed-meshheading:14618390-Genetic Predisposition to Disease,
pubmed-meshheading:14618390-Homozygote,
pubmed-meshheading:14618390-Humans,
pubmed-meshheading:14618390-Male,
pubmed-meshheading:14618390-Odds Ratio,
pubmed-meshheading:14618390-Polymerase Chain Reaction,
pubmed-meshheading:14618390-Polymorphism, Genetic,
pubmed-meshheading:14618390-Risk Factors
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| pubmed:year |
2004
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| pubmed:articleTitle |
Apolipoprotein B-100 XbaI gene polymorphism in gallbladder cancer.
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| pubmed:affiliation |
Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226014, India.
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| pubmed:publicationType |
Journal Article,
Comparative Study
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