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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
2003-11-17
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pubmed:abstractText |
Effective new therapies are needed for rheumatoid arthritis. Current therapies target the products of activated macrophages; however, T cells also have an important role in rheumatoid arthritis. A fusion protein--cytotoxic T-lymphocyte-associated antigen 4-IgG1 (CTLA4Ig)--is the first in a new class of drugs known as costimulation blockers being evaluated for the treatment of rheumatoid arthritis. CTLA4Ig binds to CD80 and CD86 on antigen-presenting cells, blocking the engagement of CD28 on T cells and preventing T-cell activation. A preliminary study showed that CTLA4Ig may be effective for the treatment of rheumatoid arthritis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1533-4406
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pubmed:author |
pubmed-author:AltenRiekeR,
pubmed-author:BeckerJean-ClaudeJC,
pubmed-author:Di GiorgioEduardoE,
pubmed-author:DougadosMaximeM,
pubmed-author:EmeryPaulP,
pubmed-author:HagertyDavid TDT,
pubmed-author:KremerJoel MJM,
pubmed-author:LeonMarcM,
pubmed-author:MorelandLarry WLW,
pubmed-author:NuamahIsaac FIF,
pubmed-author:RussellAnthonyA,
pubmed-author:SteinfeldSergeS,
pubmed-author:WesthovensReneR,
pubmed-author:WilliamsG RhysGR
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pubmed:copyrightInfo |
Copyright 2003 Massachusetts Medical Society
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pubmed:issnType |
Electronic
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pubmed:day |
13
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pubmed:volume |
349
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1907-15
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pubmed:dateRevised |
2006-5-17
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pubmed:meshHeading |
pubmed-meshheading:14614165-Adult,
pubmed-meshheading:14614165-Aged,
pubmed-meshheading:14614165-Aged, 80 and over,
pubmed-meshheading:14614165-Antibodies,
pubmed-meshheading:14614165-Arthritis, Rheumatoid,
pubmed-meshheading:14614165-Double-Blind Method,
pubmed-meshheading:14614165-Female,
pubmed-meshheading:14614165-Humans,
pubmed-meshheading:14614165-Immunoconjugates,
pubmed-meshheading:14614165-Lymphocyte Activation,
pubmed-meshheading:14614165-Male,
pubmed-meshheading:14614165-Middle Aged,
pubmed-meshheading:14614165-T-Lymphocytes
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pubmed:year |
2003
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pubmed:articleTitle |
Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig.
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pubmed:affiliation |
Center for Rheumatology, Albany, NY 12206, USA. jkremer@joint-docs.com
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
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