Source:http://linkedlifedata.com/resource/pubmed/id/14611853
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
17
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pubmed:dateCreated |
2003-11-12
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pubmed:abstractText |
A series of compounds containing an N-(4'-substituted-3'-nitrophenyl)sydnone moiety with potential antitumor activity was prepared based on active analogues. The rationale behind the design of these compounds is presented along with the 4-step synthetic route to the derivatives in the 4'-position of the phenyl sydnone framework. Out of the six novel compounds, the 4'-fluoro derivative has an improved activity against all three cell lines as compared to the earlier leads.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0960-894X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2899-901
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:14611853-Antineoplastic Agents,
pubmed-meshheading:14611853-Benzene Derivatives,
pubmed-meshheading:14611853-Cell Death,
pubmed-meshheading:14611853-Cell Line, Tumor,
pubmed-meshheading:14611853-Drug Design,
pubmed-meshheading:14611853-Drug Screening Assays, Antitumor,
pubmed-meshheading:14611853-Humans,
pubmed-meshheading:14611853-Sydnones
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pubmed:year |
2003
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pubmed:articleTitle |
Synthesis and biological evaluation of a novel phenyl substituted sydnone series as potential antitumor agents.
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pubmed:affiliation |
Department of Chemistry and Biochemistry, University of the Sciences in Philadelphia, PA 19104, USA.
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pubmed:publicationType |
Journal Article
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