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pubmed-article:14611852pubmed:abstractTextA novel series of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents have been identified. These compounds show non-selective inhibitory properties against a panel of protein tyrosine phosphatases including PTP1B. Compounds 12 and 13 display oral glucose lowering effects in ob/ob mice.lld:pubmed
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pubmed-article:14611852pubmed:articleTitleIdentification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity.lld:pubmed
pubmed-article:14611852pubmed:affiliationRoche Research Center, Hoffmann-LaRoche Inc., Nutley, NJ 07110, USA. kevin.guertin@roche.comlld:pubmed
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