Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
2003-11-12
pubmed:abstractText
A novel series of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents have been identified. These compounds show non-selective inhibitory properties against a panel of protein tyrosine phosphatases including PTP1B. Compounds 12 and 13 display oral glucose lowering effects in ob/ob mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0960-894X
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2895-8
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:14611852-Administration, Oral, pubmed-meshheading:14611852-Animals, pubmed-meshheading:14611852-Biological Availability, pubmed-meshheading:14611852-Blood Glucose, pubmed-meshheading:14611852-Diamines, pubmed-meshheading:14611852-Disease Models, Animal, pubmed-meshheading:14611852-Dithiothreitol, pubmed-meshheading:14611852-Enzyme Inhibitors, pubmed-meshheading:14611852-Hypoglycemic Agents, pubmed-meshheading:14611852-Inhibitory Concentration 50, pubmed-meshheading:14611852-Injections, Intravenous, pubmed-meshheading:14611852-Male, pubmed-meshheading:14611852-Mice, pubmed-meshheading:14611852-Mice, Inbred C57BL, pubmed-meshheading:14611852-Mice, Obese, pubmed-meshheading:14611852-Protein Tyrosine Phosphatases, pubmed-meshheading:14611852-Structure-Activity Relationship, pubmed-meshheading:14611852-Triazines
pubmed:year
2003
pubmed:articleTitle
Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity.
pubmed:affiliation
Roche Research Center, Hoffmann-LaRoche Inc., Nutley, NJ 07110, USA. kevin.guertin@roche.com
pubmed:publicationType
Journal Article