| pubmed-article:14611851 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14611851 | lifeskim:mentions | umls-concept:C0003392 | lld:lifeskim |
| pubmed-article:14611851 | lifeskim:mentions | umls-concept:C0596402 | lld:lifeskim |
| pubmed-article:14611851 | lifeskim:mentions | umls-concept:C0000985 | lld:lifeskim |
| pubmed-article:14611851 | lifeskim:mentions | umls-concept:C0014898 | lld:lifeskim |
| pubmed-article:14611851 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:14611851 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:14611851 | lifeskim:mentions | umls-concept:C0662351 | lld:lifeskim |
| pubmed-article:14611851 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:14611851 | pubmed:dateCreated | 2003-11-12 | lld:pubmed |
| pubmed-article:14611851 | pubmed:abstractText | 2-Phenyl-4-quinolone acetic acids and their esters were synthesized and evaluated for interaction with tubulin and for cytotoxicity against a panel of human tumor cell lines. 2-Phenyl- and 2-(2'-fluorophenyl)-4-quinolone-8-acetic acids (11 and 12) displayed potent cytotoxicity with ED(50) values at nanomolar concentrations, but had minimal activity against tubulin polymerization. 2-(2'-Fluorophenyl)-4-quinolone-6-acetic acid (3) and 2-(2'-fluorophenyl)-4-quinolone-8-acetic acid methyl ester (10) moderately inhibited tubulin polymerization. | lld:pubmed |
| pubmed-article:14611851 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14611851 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14611851 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14611851 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14611851 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14611851 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14611851 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14611851 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14611851 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14611851 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14611851 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:14611851 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:14611851 | pubmed:author | pubmed-author:BastowKenneth... | lld:pubmed |
| pubmed-article:14611851 | pubmed:author | pubmed-author:LeeKuo-Hsiung... | lld:pubmed |
| pubmed-article:14611851 | pubmed:author | pubmed-author:NakanishiYuka... | lld:pubmed |
| pubmed-article:14611851 | pubmed:author | pubmed-author:BrossiArnoldA | lld:pubmed |
| pubmed-article:14611851 | pubmed:author | pubmed-author:XiaPengP | lld:pubmed |
| pubmed-article:14611851 | pubmed:author | pubmed-author:HamelErnestE | lld:pubmed |
| pubmed-article:14611851 | pubmed:author | pubmed-author:XiaYiY | lld:pubmed |
| pubmed-article:14611851 | pubmed:author | pubmed-author:YangZheng-YuZ... | lld:pubmed |
| pubmed-article:14611851 | pubmed:author | pubmed-author:NampoothiriPr... | lld:pubmed |
| pubmed-article:14611851 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14611851 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:14611851 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:14611851 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14611851 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14611851 | pubmed:pagination | 2891-3 | lld:pubmed |
| pubmed-article:14611851 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:14611851 | pubmed:meshHeading | pubmed-meshheading:14611851... | lld:pubmed |
| pubmed-article:14611851 | pubmed:meshHeading | pubmed-meshheading:14611851... | lld:pubmed |
| pubmed-article:14611851 | pubmed:meshHeading | pubmed-meshheading:14611851... | lld:pubmed |
| pubmed-article:14611851 | pubmed:meshHeading | pubmed-meshheading:14611851... | lld:pubmed |
| pubmed-article:14611851 | pubmed:meshHeading | pubmed-meshheading:14611851... | lld:pubmed |
| pubmed-article:14611851 | pubmed:meshHeading | pubmed-meshheading:14611851... | lld:pubmed |
| pubmed-article:14611851 | pubmed:meshHeading | pubmed-meshheading:14611851... | lld:pubmed |
| pubmed-article:14611851 | pubmed:meshHeading | pubmed-meshheading:14611851... | lld:pubmed |
| pubmed-article:14611851 | pubmed:meshHeading | pubmed-meshheading:14611851... | lld:pubmed |
| pubmed-article:14611851 | pubmed:meshHeading | pubmed-meshheading:14611851... | lld:pubmed |
| pubmed-article:14611851 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14611851 | pubmed:articleTitle | Antitumor agents. Part 226: synthesis and cytotoxicity of 2-phenyl-4-quinolone acetic acids and their esters. | lld:pubmed |
| pubmed-article:14611851 | pubmed:affiliation | Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599, USA. | lld:pubmed |
| pubmed-article:14611851 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14611851 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:14611851 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14611851 | lld:pubmed |
