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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2003-11-12
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pubmed:abstractText |
2-Phenyl-4-quinolone acetic acids and their esters were synthesized and evaluated for interaction with tubulin and for cytotoxicity against a panel of human tumor cell lines. 2-Phenyl- and 2-(2'-fluorophenyl)-4-quinolone-8-acetic acids (11 and 12) displayed potent cytotoxicity with ED(50) values at nanomolar concentrations, but had minimal activity against tubulin polymerization. 2-(2'-Fluorophenyl)-4-quinolone-6-acetic acid (3) and 2-(2'-fluorophenyl)-4-quinolone-8-acetic acid methyl ester (10) moderately inhibited tubulin polymerization.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2891-3
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14611851-Acetic Acids,
pubmed-meshheading:14611851-Antineoplastic Agents,
pubmed-meshheading:14611851-Cell Line, Tumor,
pubmed-meshheading:14611851-Drug Screening Assays, Antitumor,
pubmed-meshheading:14611851-Esters,
pubmed-meshheading:14611851-Humans,
pubmed-meshheading:14611851-Inhibitory Concentration 50,
pubmed-meshheading:14611851-Quinolones,
pubmed-meshheading:14611851-Structure-Activity Relationship,
pubmed-meshheading:14611851-Tubulin
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pubmed:year |
2003
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pubmed:articleTitle |
Antitumor agents. Part 226: synthesis and cytotoxicity of 2-phenyl-4-quinolone acetic acids and their esters.
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pubmed:affiliation |
Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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