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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2003-11-12
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pubmed:abstractText |
Four racemic phenyl-substituted analogues 3-6 of the potent nicotinic agonist UB-165 1 have been synthesised and evaluated against the alpha(4)beta(2), alpha(3)beta(4), and alpha(7) neuronal nicotinic receptors. The 2'-phenyl derivative 3 shows no activity at these major receptor subtypes, while the 4'-phenyl analogue 4 shows an enhanced level of alpha(7) selectivity as compared to UB-165 and deschloro UB-165 2. These results are discussed within the context of recent pharmacophore models.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2825-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14611837-Animals,
pubmed-meshheading:14611837-Benzene Derivatives,
pubmed-meshheading:14611837-Bridged Compounds,
pubmed-meshheading:14611837-Neurons,
pubmed-meshheading:14611837-Nicotinic Agonists,
pubmed-meshheading:14611837-Pyridines,
pubmed-meshheading:14611837-Radioligand Assay,
pubmed-meshheading:14611837-Rats,
pubmed-meshheading:14611837-Receptors, Nicotinic,
pubmed-meshheading:14611837-Stereoisomerism,
pubmed-meshheading:14611837-Structure-Activity Relationship
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pubmed:year |
2003
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pubmed:articleTitle |
Synthesis and nicotinic binding of novel phenyl derivatives of UB-165. Identifying factors associated with alpha7 selectivity.
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pubmed:affiliation |
School of Chemistry, University of Bristol, UK.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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