Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2003-11-11
pubmed:abstractText
Regulatory T lymphocytes play a central role in maintaining an immunological balance between responsiveness to foreign antigens and suppression of responsiveness to self-antigens. We recently discovered that infection of mice with Friend retrovirus skewed the balance toward suppression by causing an expansion of immunosuppressive regulatory cells. Immunosuppression was transferable to naive mice by adoptive transfer of CD4+ T cells. Our current studies examine the in vivo role of CD4+ regulatory T lymphocytes in controlling normal immune responses and investigate ways to prevent or reverse immunosuppression by these cells. Regulatory cells have now been implicated as factors in the establishment and/or maintenance of persistence in human infections with parasites, Bordetella pertussis, hepatitis C virus, and HIV. Thus findings from the Friend virus mouse model may provide insights into new therapies or preventive strategies against persistent pathogens.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1528-2511
pubmed:author
pubmed:issnType
Print
pubmed:volume
252
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
194-9; discussion 199-210
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
CD4+ regulatory T cells in chronic viral infection.
pubmed:affiliation
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
pubmed:publicationType
Journal Article, Review