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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1993-1-13
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pubmed:abstractText |
The propositus erythrocytes with phenotype En(a-), which was found in the first example of a Japanese family, reacted with anti-N serum weaker than the ordinary phenotype N erythrocytes. When the erythrocyte membranes of the propositus were subjected to SDS-PAGE, no glycophorin A was observed on the gel by PAS staining, whereas glycophorin B band was observed. The S and the s antigens of the propositus erythrocytes were appeared to be normal. These results suggested that N activity of the propositus erythrocytes may be derived from glycophorin B components on the erythrocyte membranes. The amounts of bound sialic acid of the erythrocyte membranes were significantly lower in the En(a-) erythrocytes than the ordinary OMN erythrocytes. Neither the OMN nor the En(a-) erythrocytes showed the agglutinability to Arachis hypogaea lectin. The number of lectin receptor sites on the En(a-) erythrocyte membranes was significantly lower than on the OMN erythrocyte membranes for Limulus polyphemus, Triticum vurgaris and Bauhinia purpurea lectins. These results provide further support for the contention that En(a-) cells lack the glycophorin A as major erythrocytes sialoglycoprotein on the membranes.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0047-1887
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
301-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1460794-Asian Continental Ancestry Group,
pubmed-meshheading:1460794-Carbohydrate Metabolism,
pubmed-meshheading:1460794-Erythrocyte Aggregation,
pubmed-meshheading:1460794-Erythrocyte Membrane,
pubmed-meshheading:1460794-Erythrocytes,
pubmed-meshheading:1460794-Genetic Variation,
pubmed-meshheading:1460794-Glycophorin,
pubmed-meshheading:1460794-Humans,
pubmed-meshheading:1460794-Japan,
pubmed-meshheading:1460794-Phenotype,
pubmed-meshheading:1460794-Receptors, Mitogen
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pubmed:year |
1992
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pubmed:articleTitle |
Serological and biochemical studies on En(a-) human erythrocytes in a Japanese family.
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pubmed:affiliation |
Department of Legal Medicine, School of Medicine, Keio University.
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pubmed:publicationType |
Journal Article
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