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rdf:type |
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lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0017262,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0033640,
umls-concept:C0035647,
umls-concept:C0036525,
umls-concept:C0185117,
umls-concept:C0205217,
umls-concept:C0205314,
umls-concept:C0334227,
umls-concept:C0679622,
umls-concept:C1522484,
umls-concept:C2911684
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pubmed:issue |
2
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pubmed:dateCreated |
2003-11-10
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pubmed:abstractText |
A novel protein kinase named BRPK was isolated and partially characterized. BRPK was expressed at a higher level in three carcinoma cell lines with higher metastatic potential. Mouse and human BRPK cDNAs are well conserved and encode 580 and 581 amino acids, respectively. BRPK has a serine/threonine-type protein kinase domain, and the recombinant proteins of BRPK were capable of autophosphorylation. The results of a comparative sequence analysis indicated a possible link of BRPK to BRAP2. BRAP2 is known to bind the nuclear localization signal of BRCA1. We cloned mouse BRAP2 cDNA and showed the presence of isoforms.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0304-3835
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
201
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
195-201
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:14607334-Amino Acid Sequence,
pubmed-meshheading:14607334-Animals,
pubmed-meshheading:14607334-BRCA1 Protein,
pubmed-meshheading:14607334-Carrier Proteins,
pubmed-meshheading:14607334-Cell Line,
pubmed-meshheading:14607334-Cloning, Molecular,
pubmed-meshheading:14607334-Colonic Neoplasms,
pubmed-meshheading:14607334-DNA, Complementary,
pubmed-meshheading:14607334-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:14607334-Humans,
pubmed-meshheading:14607334-Melanoma,
pubmed-meshheading:14607334-Mice,
pubmed-meshheading:14607334-Molecular Sequence Data,
pubmed-meshheading:14607334-Phosphorylation,
pubmed-meshheading:14607334-Protein Kinases,
pubmed-meshheading:14607334-Sequence Homology, Amino Acid,
pubmed-meshheading:14607334-Skin Neoplasms,
pubmed-meshheading:14607334-Transfection,
pubmed-meshheading:14607334-Tumor Cells, Cultured,
pubmed-meshheading:14607334-Ubiquitin-Protein Ligases
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pubmed:year |
2003
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pubmed:articleTitle |
BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential.
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pubmed:affiliation |
Department of Cell Biology, Okayama University Graduate School of Medicine and Dentistry, Shikata-chou, Okayama 700-8558, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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