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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2003-11-10
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pubmed:abstractText |
Signaling involved in osteoblastic cell differentiation remains largely unknown. This study further investigates mechanisms involved in BMP-2-induced osteoblastic cell differentiation. We report that BMP-2 can activate JNK and p38 in osteoblastic cells and provide evidences that these MAP kinases have distinct roles in regulating alkaline phosphatase and osteocalcin expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anthracenes,
http://linkedlifedata.com/resource/pubmed/chemical/Bmp2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 2,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/anthra(1,9-cd)pyrazol-6(2H)-one,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0884-0431
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2060-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:14606520-3T3 Cells,
pubmed-meshheading:14606520-Animals,
pubmed-meshheading:14606520-Anthracenes,
pubmed-meshheading:14606520-Bone Morphogenetic Protein 2,
pubmed-meshheading:14606520-Bone Morphogenetic Proteins,
pubmed-meshheading:14606520-Cell Differentiation,
pubmed-meshheading:14606520-Cells, Cultured,
pubmed-meshheading:14606520-Enzyme Activation,
pubmed-meshheading:14606520-Enzyme Inhibitors,
pubmed-meshheading:14606520-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:14606520-MAP Kinase Signaling System,
pubmed-meshheading:14606520-Mice,
pubmed-meshheading:14606520-Mitogen-Activated Protein Kinases,
pubmed-meshheading:14606520-Osteoblasts,
pubmed-meshheading:14606520-Skull,
pubmed-meshheading:14606520-Transforming Growth Factor beta,
pubmed-meshheading:14606520-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2003
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pubmed:articleTitle |
Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation.
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pubmed:affiliation |
Division of Bone Diseases, Department of Geriatrics, University Hospital of Geneva, Geneva, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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