Linked Life Data

14605255

Source:http://linkedlifedata.com/resource/pubmed/id/14605255

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-12-22
pubmed:abstractText
Spontaneous preterm birth due to intrauterine infection is associated with increased concentrations of cytokines in amniotic fluid and in the airways at birth. Intra-amniotic IL-1 induces fetal lung maturity, consistent with the decrease in the incidence of respiratory distress syndrome (RDS) in intrauterine inflammation. On the other hand, antenatal corticosteroid decreases the incidence of RDS in infants born prematurely. The aim of the present study was to investigate the interaction between IL-1 and glucocorticoid in the expression of the surfactant proteins SP-A, -B, and -C. Lung explants from rabbit fetuses at 22 (immature), 27 (transitional), and 30 (mature) d of gestation (term, 30-31 d) and on d 1 after term birth were cultured with dexamethasone (Dx), IL-1alpha, or vehicle in the presence or absence of actinomycin D. According to the present results, IL-1alpha and Dx additively increased the expression of SP-A and SP-B on d 22. Later in gestation, SP-B and SP-C were suppressed by IL-1, whereas glucocorticoid tended to increase the expression of SP-B and SP-C and prevented the IL-1-induced suppression of SP. IL-1alpha and steroid interactively increased the stability of SP mRNA compared with the single agonist, possibly explaining the additive effects on the SP mRNA levels. The present results reveal beneficial additive effects of glucocorticoid and cytokine on lung surfactant. They may explain some of the acute beneficial effects of glucocorticoid therapy in chorioamnionitis before premature birth and in inflammatory lung disease after birth.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0031-3998
pubmed:author
pubmed:issnType
Print
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
55-60
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:14605255-Adrenal Cortex Hormones, pubmed-meshheading:14605255-Animals, pubmed-meshheading:14605255-Animals, Newborn, pubmed-meshheading:14605255-Dexamethasone, pubmed-meshheading:14605255-Female, pubmed-meshheading:14605255-Gene Expression, pubmed-meshheading:14605255-Humans, pubmed-meshheading:14605255-Infant, Newborn, pubmed-meshheading:14605255-Interleukin-1, pubmed-meshheading:14605255-Lung, pubmed-meshheading:14605255-Organ Culture Techniques, pubmed-meshheading:14605255-Pneumonia, pubmed-meshheading:14605255-Pregnancy, pubmed-meshheading:14605255-Pulmonary Surfactant-Associated Protein A, pubmed-meshheading:14605255-Pulmonary Surfactant-Associated Protein B, pubmed-meshheading:14605255-Pulmonary Surfactant-Associated Protein C, pubmed-meshheading:14605255-RNA, Messenger, pubmed-meshheading:14605255-Rabbits, pubmed-meshheading:14605255-Respiratory Distress Syndrome, Newborn
pubmed:year
2004
pubmed:articleTitle
Inflammatory and anti-inflammatory responsiveness of surfactant proteins in fetal and neonatal rabbit lung.
pubmed:affiliation
Department of Pediatrics and Biocenter Oulu, University of Oulu, Kajaanintie 52, 90220 Oulu, Finland. mikko.hallman@oulu.fi
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't