Linked Life Data

14605140

Source:http://linkedlifedata.com/resource/pubmed/id/14605140

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pubmed-article:14605140pubmed:abstractTextAssessment of cure of Trypanosoma cruzi infection by antibody seroconversion usually involves several years of follow-up. Parasitological negativity is useless for cure assessment, since even untreated patients mostly show negative results; conversely, positive tests are of great value because they indicate treatment failure. Here, PCR was used to assess the rate of specific chemotherapy failure in a well-characterized Brazilian cohort of T. cruzi-seropositive children, who were enrolled in a field trial of benznidazole (Bz) efficacy. Paired blood samples from 111 children were taken at baseline and 36 months after treatment with either Bz (n = 58) or a placebo (n = 53). DNA extraction and PCR amplification were carried out as previously described, and hybridization was performed with all PCR products. At the end of follow-up, PCR was positive for 39.6% of the patients in the Bz group versus 64.2% in the placebo group (P = 0.01). Untreated patients had a 1.6-fold-higher chance of remaining positive by PCR than those in the Bz group (P < 0.05). We conclude that PCR is a useful tool for revealing therapeutic failure of T. cruzi infection on a short-term basis.lld:pubmed
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pubmed-article:14605140pubmed:authorpubmed-author:ChiariEglerElld:pubmed
pubmed-article:14605140pubmed:authorpubmed-author:MacedoAndréa...lld:pubmed
pubmed-article:14605140pubmed:authorpubmed-author:SilvaSimonne...lld:pubmed
pubmed-article:14605140pubmed:authorpubmed-author:GalvãoLúcia...lld:pubmed
pubmed-article:14605140pubmed:authorpubmed-author:LuquettiAleja...lld:pubmed
pubmed-article:14605140pubmed:authorpubmed-author:AndradeAna...lld:pubmed
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pubmed-article:14605140pubmed:pagination5066-70lld:pubmed
pubmed-article:14605140pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:14605140pubmed:year2003lld:pubmed
pubmed-article:14605140pubmed:articleTitlePCR assay for monitoring Trypanosoma cruzi parasitemia in childhood after specific chemotherapy.lld:pubmed
pubmed-article:14605140pubmed:affiliationDepartamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.lld:pubmed
pubmed-article:14605140pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:14605140pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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