Source:http://linkedlifedata.com/resource/pubmed/id/14604966
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2004-2-20
|
| pubmed:abstractText |
The Edmonston vaccine strain of measles virus (MV-Edm) propagates efficiently in a broad range of human tumor cells, killing them selectively. However, the oncolytic potency of MV-Edm in different human tumor xenograft therapy models is highly variable and there is no convenient way to map the distribution of virus-infected tissues in vivo. To enhance the oncolytic potency of MV-Edm against radiosensitive malignancies and to facilitate noninvasive imaging of infected tissues, we generated a recombinant MV-Edm encoding the human thyroidal iodide symporter (NIS). MV-NIS replicated almost as efficiently as unmodified MV-Edm, and human tumor cells efficiently concentrated radioiodine when infected with MV-NIS. Intratumoral spread of MV-NIS was noninvasively demonstrated by serial gamma-camera imaging of iodine-123 (123I) uptake both in MV-sensitive KAS-6/1 myeloma xenografts, which regressed completely after a single intravenous dose of MV-NIS, and in MM1 myeloma xenografts, which were unresponsive to MVNIS therapy. However, MV-resistant MM1 tumors regressed completely when 131I was administered 9 days after a single intravenous injection of MV-NIS (radiovirotherapy). 131I alone had no effect on MM1 tumor growth. While the potential hematopoietic toxicity of this new therapy requires further evaluation, image-guided radiovirotherapy is a promising new approach to the treatment of multiple myeloma, an incurable but highly radiosensitive plasma cell malignancy. Testing in other radiosensitive cancers is warranted.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Iodine Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Symporters,
http://linkedlifedata.com/resource/pubmed/chemical/sodium-iodide symporter
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0006-4971
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
103
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1641-6
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:14604966-Animals,
pubmed-meshheading:14604966-Cell Line,
pubmed-meshheading:14604966-Cell Line, Tumor,
pubmed-meshheading:14604966-Cercopithecus aethiops,
pubmed-meshheading:14604966-Combined Modality Therapy,
pubmed-meshheading:14604966-DNA, Complementary,
pubmed-meshheading:14604966-Female,
pubmed-meshheading:14604966-Genetic Techniques,
pubmed-meshheading:14604966-Humans,
pubmed-meshheading:14604966-Interleukin-6,
pubmed-meshheading:14604966-Iodine Radioisotopes,
pubmed-meshheading:14604966-Measles virus,
pubmed-meshheading:14604966-Mice,
pubmed-meshheading:14604966-Mice, SCID,
pubmed-meshheading:14604966-Multiple Myeloma,
pubmed-meshheading:14604966-Neoplasm Transplantation,
pubmed-meshheading:14604966-Symporters,
pubmed-meshheading:14604966-Thyroid Gland,
pubmed-meshheading:14604966-Time Factors,
pubmed-meshheading:14604966-Vero Cells,
pubmed-meshheading:14604966-Xenograft Model Antitumor Assays
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Image-guided radiovirotherapy for multiple myeloma using a recombinant measles virus expressing the thyroidal sodium iodide symporter.
|
| pubmed:affiliation |
Molecular Medicine Program, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|