Source:http://linkedlifedata.com/resource/pubmed/id/14603996
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2003-11-7
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| pubmed:abstractText |
An inhibitor of interferon antiviral activity, which is absent in healthy HIV-seronegative persons, was detected in the sera of all 29 HIV-seropositive study participants. The relationship of the level of interferon inhibitor to CD4 count and HIV-RNA copy number was statistically significant in distinct models. Levels of interferon inhibitor declined by an average of 41-60% in patients who underwent a change in anti-retroviral therapy. Interferon inhibitor levels appear to decline as CD4 cell count rises and HIV-RNA levels fall. This suggests that interferon inhibitor may have a significant role in the host immune response to HIV infection.
|
| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0882-0139
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
32
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
299-312
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:14603996-Adult,
pubmed-meshheading:14603996-Anti-Retroviral Agents,
pubmed-meshheading:14603996-CD4 Lymphocyte Count,
pubmed-meshheading:14603996-Female,
pubmed-meshheading:14603996-Fibroblasts,
pubmed-meshheading:14603996-HIV Infections,
pubmed-meshheading:14603996-HIV Seropositivity,
pubmed-meshheading:14603996-HIV-1,
pubmed-meshheading:14603996-Humans,
pubmed-meshheading:14603996-Interferon-alpha,
pubmed-meshheading:14603996-Interferons,
pubmed-meshheading:14603996-Male,
pubmed-meshheading:14603996-Middle Aged,
pubmed-meshheading:14603996-Patient Selection,
pubmed-meshheading:14603996-RNA, Viral,
pubmed-meshheading:14603996-Regression Analysis,
pubmed-meshheading:14603996-Vesicular stomatitis Indiana virus,
pubmed-meshheading:14603996-Viral Load
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Serum interferon inhibitor declines in patients with HIV-1 infection after a change in antiretroviral therapy.
|
| pubmed:affiliation |
Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. kailash.chadha@roswellpark.org
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|