Source:http://linkedlifedata.com/resource/pubmed/id/14603341
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2003-12-17
|
| pubmed:abstractText |
To define reproducible criteria for subgroups of diffuse large B-cell lymphomas (DLBCL), including lymphomas with plasmablastic/plasmacytoid features (PB/PC-Fs), we investigated 66 DLBCL; the samples were categorized as either centroblastic (CB), immunoblastic (IB) or PB/PC-F applying standardized morphologic criteria. Blinded specimens were reviewed by three independent pathologists. The final consensus classification included 44 CB (67%), seven IB (10%) and 15 PB/PC-F (23%). The interobserver agreement between two centers (Vienna, Würzburg) was 93.5%. Most PB/PC-F were CD20+, cIgM+, MUM-1+, CD138+/-, bcl-6-, corresponding to an activated B-cell phenotype. Immunoglobulin-V(H) gene mutation analysis was consistent with a germinal or postgerminal center-cell origin. By fluorescence in situ hybridization analysis, 11/13 (85%) PB/PC-F had a monoallelic TP53 deletion. The pretreatment characteristics of patients with PB/PC-F included a tendency for more B symptoms, extranodal disease and a higher IPI. Importantly, PB/PC-F were resistant to standard chemotherapy (complete remission rate 47%, relapse rate 71%) and even autologous stem-cell transplantation. The median overall survival (OS) (14 months, P<0.002) and disease-free survival (6 months, P=0.02) were significantly shorter compared to patients with CB and IB. The OS difference was pronounced within the low and low-intermediate IPI risk group (P<0.001). Our data indicate a strong association of plasmablastic/plasmacytoid morphology with TP53 deletions, poor response to chemotherapy and short survival.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0887-6924
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| pubmed:author |
pubmed-author:AckermannJJ,
pubmed-author:ChottAA,
pubmed-author:DittrichCC,
pubmed-author:DrachJJ,
pubmed-author:GreinixH THT,
pubmed-author:HausenMM,
pubmed-author:JaegerUU,
pubmed-author:KaufmannJJ,
pubmed-author:LechnerKK,
pubmed-author:LutyEE,
pubmed-author:MannhalterCC,
pubmed-author:OttGG,
pubmed-author:PötterRR,
pubmed-author:Simonitsch-KluppII,
pubmed-author:SkrabsCC,
pubmed-author:WeltermannAA
|
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
146-55
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:14603341-Adult,
pubmed-meshheading:14603341-Aged,
pubmed-meshheading:14603341-Aged, 80 and over,
pubmed-meshheading:14603341-Antigens, Neoplasm,
pubmed-meshheading:14603341-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:14603341-Biological Markers,
pubmed-meshheading:14603341-Female,
pubmed-meshheading:14603341-Follow-Up Studies,
pubmed-meshheading:14603341-Genes, Immunoglobulin,
pubmed-meshheading:14603341-Genes, p53,
pubmed-meshheading:14603341-Germinal Center,
pubmed-meshheading:14603341-Herpesvirus 4, Human,
pubmed-meshheading:14603341-Humans,
pubmed-meshheading:14603341-Immunophenotyping,
pubmed-meshheading:14603341-In Situ Hybridization, Fluorescence,
pubmed-meshheading:14603341-Lymphoma, B-Cell,
pubmed-meshheading:14603341-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:14603341-Lymphoma, Large-Cell, Immunoblastic,
pubmed-meshheading:14603341-Male,
pubmed-meshheading:14603341-Middle Aged,
pubmed-meshheading:14603341-Plasma Cells,
pubmed-meshheading:14603341-Prognosis,
pubmed-meshheading:14603341-RNA, Viral,
pubmed-meshheading:14603341-Sequence Deletion,
pubmed-meshheading:14603341-Survival Rate,
pubmed-meshheading:14603341-Treatment Outcome
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Diffuse large B-cell lymphomas with plasmablastic/plasmacytoid features are associated with TP53 deletions and poor clinical outcome.
|
| pubmed:affiliation |
Department of Clinical Pathology, University of Vienna, Vienna, Austria.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|