Linked Life Data

14602968

Source:http://linkedlifedata.com/resource/pubmed/id/14602968

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2003-11-6
pubmed:abstractText
Some researchers have speculated that the senescence-retarding effect of caloric restriction on laboratory rodents is an artifact of overfeeding under captive conditions. The argument posits that mice in nature are chronically calorically restricted; therefore, the typical laboratory protocol of restricting animals to 60% of their ad lib food intake more realistically replicates life in the field: the conditions under which the animals' physiology has been designed by natural selection to thrive. The hypothesis concludes that instead of comparing control animals with restricted animals, we are in fact comparing overfed animals with adequately fed ones, and, not surprisingly, the overfed ones die younger. In this Perspective, the author discusses the merits and drawbacks of this hypothesis in light of energy consumption data for various types of mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1539-6150
pubmed:author
pubmed:issnType
Electronic
pubmed:day
7
pubmed:volume
2001
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
pe3
pubmed:dateRevised
2004-8-3
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Does caloric restriction in the laboratory simply prevent overfeeding and return house mice to their natural level of food intake?
pubmed:affiliation
Department of Biological Sciences, University of Idaho, Moscow, ID 83844-3051, USA. austad@uidaho.edu
pubmed:publicationType
Journal Article