| pubmed-article:14602933 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14602933 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:14602933 | lifeskim:mentions | umls-concept:C0021943 | lld:lifeskim |
| pubmed-article:14602933 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:14602933 | lifeskim:mentions | umls-concept:C1709450 | lld:lifeskim |
| pubmed-article:14602933 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:14602933 | pubmed:dateCreated | 2003-11-6 | lld:pubmed |
| pubmed-article:14602933 | pubmed:abstractText | The Cre/loxP recombination system is a commonly used tool to alter the mouse genome in a conditional manner by deletion or inversion of loxP-flanked DNA segments. While Cre-mediated deletion is essentially unidirectional, inversion is reversible and therefore does not allow the stable alteration of gene function in cells that constitutively express Cre. Site-directed mutagenesis yielded a pair of asymmetric loxP sites (lox66 and lox71) that display a favorable forward reaction equilibrium. Here, we demonstrate that lox66/lox71 mediates efficient and predominantly unidirectional inversion of a switch substrate targeted to the mouse genome in combination with either inducible or cell type-specific cre-transgenes in vivo. | lld:pubmed |
| pubmed-article:14602933 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14602933 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14602933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14602933 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14602933 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:14602933 | pubmed:issn | 1362-4962 | lld:pubmed |
| pubmed-article:14602933 | pubmed:author | pubmed-author:RajewskyKlaus... | lld:pubmed |
| pubmed-article:14602933 | pubmed:author | pubmed-author:OtipobyKevin... | lld:pubmed |
| pubmed-article:14602933 | pubmed:author | pubmed-author:OberdoerfferP... | lld:pubmed |
| pubmed-article:14602933 | pubmed:author | pubmed-author:MaruyamaMitsu... | lld:pubmed |
| pubmed-article:14602933 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:14602933 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:14602933 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:14602933 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14602933 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14602933 | pubmed:pagination | e140 | lld:pubmed |
| pubmed-article:14602933 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:14602933 | pubmed:meshHeading | pubmed-meshheading:14602933... | lld:pubmed |
| pubmed-article:14602933 | pubmed:meshHeading | pubmed-meshheading:14602933... | lld:pubmed |
| pubmed-article:14602933 | pubmed:meshHeading | pubmed-meshheading:14602933... | lld:pubmed |
| pubmed-article:14602933 | pubmed:meshHeading | pubmed-meshheading:14602933... | lld:pubmed |
| pubmed-article:14602933 | pubmed:meshHeading | pubmed-meshheading:14602933... | lld:pubmed |
| pubmed-article:14602933 | pubmed:meshHeading | pubmed-meshheading:14602933... | lld:pubmed |
| pubmed-article:14602933 | pubmed:meshHeading | pubmed-meshheading:14602933... | lld:pubmed |
| pubmed-article:14602933 | pubmed:meshHeading | pubmed-meshheading:14602933... | lld:pubmed |
| pubmed-article:14602933 | pubmed:meshHeading | pubmed-meshheading:14602933... | lld:pubmed |
| pubmed-article:14602933 | pubmed:meshHeading | pubmed-meshheading:14602933... | lld:pubmed |
| pubmed-article:14602933 | pubmed:meshHeading | pubmed-meshheading:14602933... | lld:pubmed |
| pubmed-article:14602933 | pubmed:meshHeading | pubmed-meshheading:14602933... | lld:pubmed |
| pubmed-article:14602933 | pubmed:meshHeading | pubmed-meshheading:14602933... | lld:pubmed |
| pubmed-article:14602933 | pubmed:meshHeading | pubmed-meshheading:14602933... | lld:pubmed |
| pubmed-article:14602933 | pubmed:meshHeading | pubmed-meshheading:14602933... | lld:pubmed |
| pubmed-article:14602933 | pubmed:meshHeading | pubmed-meshheading:14602933... | lld:pubmed |
| pubmed-article:14602933 | pubmed:meshHeading | pubmed-meshheading:14602933... | lld:pubmed |
| pubmed-article:14602933 | pubmed:meshHeading | pubmed-meshheading:14602933... | lld:pubmed |
| pubmed-article:14602933 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14602933 | pubmed:articleTitle | Unidirectional Cre-mediated genetic inversion in mice using the mutant loxP pair lox66/lox71. | lld:pubmed |
| pubmed-article:14602933 | pubmed:affiliation | The CBR Institute for Biomedical Research, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:14602933 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14602933 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14602933 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14602933 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14602933 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14602933 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14602933 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14602933 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14602933 | lld:pubmed |
