| pubmed-article:14600574 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14600574 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:14600574 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:14600574 | lifeskim:mentions | umls-concept:C0521026 | lld:lifeskim |
| pubmed-article:14600574 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:14600574 | lifeskim:mentions | umls-concept:C1704939 | lld:lifeskim |
| pubmed-article:14600574 | lifeskim:mentions | umls-concept:C2700592 | lld:lifeskim |
| pubmed-article:14600574 | lifeskim:mentions | umls-concept:C0205390 | lld:lifeskim |
| pubmed-article:14600574 | lifeskim:mentions | umls-concept:C0678951 | lld:lifeskim |
| pubmed-article:14600574 | lifeskim:mentions | umls-concept:C1265875 | lld:lifeskim |
| pubmed-article:14600574 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:14600574 | lifeskim:mentions | umls-concept:C1318970 | lld:lifeskim |
| pubmed-article:14600574 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:14600574 | pubmed:dateCreated | 2003-11-5 | lld:pubmed |
| pubmed-article:14600574 | pubmed:abstractText | Human CD4+ T cells express P-glycoprotein (P-gp), the ATP binding cassette efflux transporter encoded by MDR1. A common MDR1 single-nucleotide polymorphism in exon 26 (C3435T), which is linked to an exon 21 polymorphism (G2677T/A) and reportedly alters expression, has been associated with greater CD4+ T-cell increases during antiretroviral therapy. P-gp overexpression prevents apoptosis and inhibits HIV-1 replication in model systems, suggesting a potential effect on T-cell turnover. This study explored relationships between MDR1 polymorphisms and phase 1 viral decay among 31 HIV-infected individuals initiating antiretroviral therapy. Position 3435 genotypes were CC in 7 (23%), CT in 14 (45%), and TT in 10 (32%). Position 2677 genotypes were GG in 8 (26%), GT in 18 (58%), and TT in 5 (16%). There was no significant relationship between allelic variants in either exon 26 or 21 and phase 1 or phase 2 viral decay, changes in lymphocyte subsets over time, or plasma trough ritonavir concentrations. It is concluded with 95% confidence that phase 1 viral decay differences between exon 26 TT and CC groups are unlikely to exceed 18%. | lld:pubmed |
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| pubmed-article:14600574 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14600574 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14600574 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14600574 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14600574 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14600574 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14600574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14600574 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14600574 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:14600574 | pubmed:issn | 1525-4135 | lld:pubmed |
| pubmed-article:14600574 | pubmed:author | pubmed-author:LiHaihongH | lld:pubmed |
| pubmed-article:14600574 | pubmed:author | pubmed-author:LandayAlanA | lld:pubmed |
| pubmed-article:14600574 | pubmed:author | pubmed-author:KimRichard... | lld:pubmed |
| pubmed-article:14600574 | pubmed:author | pubmed-author:HaasDavid WDW | lld:pubmed |
| pubmed-article:14600574 | pubmed:author | pubmed-author:LedermanMicha... | lld:pubmed |
| pubmed-article:14600574 | pubmed:author | pubmed-author:WuHulinH | lld:pubmed |
| pubmed-article:14600574 | pubmed:author | pubmed-author:WilkinsonGran... | lld:pubmed |
| pubmed-article:14600574 | pubmed:author | pubmed-author:BoschRonald... | lld:pubmed |
| pubmed-article:14600574 | pubmed:author | pubmed-author:ConnickElizab... | lld:pubmed |
| pubmed-article:14600574 | pubmed:author | pubmed-author:KesslerHarold... | lld:pubmed |
| pubmed-article:14600574 | pubmed:author | pubmed-author:KuritzkesDani... | lld:pubmed |
| pubmed-article:14600574 | pubmed:author | pubmed-author:BensonConstan... | lld:pubmed |
| pubmed-article:14600574 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14600574 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:14600574 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:14600574 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14600574 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14600574 | pubmed:pagination | 295-8 | lld:pubmed |
| pubmed-article:14600574 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:14600574 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14600574 | pubmed:articleTitle | MDR1 gene polymorphisms and phase 1 viral decay during HIV-1 infection: an adult AIDS Clinical Trials Group study. | lld:pubmed |
| pubmed-article:14600574 | pubmed:affiliation | Division of Infectious Diseases, Vanderbilt University School of Medicine, 345 24th Avenue, North, Suite 105, Nashville, TN 37212, USA. david.w.haas@vanderbilt.edu | lld:pubmed |
| pubmed-article:14600574 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14600574 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:14600574 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14600574 | pubmed:publicationType | Multicenter Study | lld:pubmed |
| pubmed-article:14600574 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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