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rdf:type |
|
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lifeskim:mentions |
umls-concept:C0001675,
umls-concept:C0019704,
umls-concept:C0021311,
umls-concept:C0205390,
umls-concept:C0521026,
umls-concept:C0678951,
umls-concept:C1265875,
umls-concept:C1318970,
umls-concept:C1704939,
umls-concept:C2603343,
umls-concept:C2700592
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pubmed:issue |
3
|
|
pubmed:dateCreated |
2003-11-5
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|
pubmed:abstractText |
Human CD4+ T cells express P-glycoprotein (P-gp), the ATP binding cassette efflux transporter encoded by MDR1. A common MDR1 single-nucleotide polymorphism in exon 26 (C3435T), which is linked to an exon 21 polymorphism (G2677T/A) and reportedly alters expression, has been associated with greater CD4+ T-cell increases during antiretroviral therapy. P-gp overexpression prevents apoptosis and inhibits HIV-1 replication in model systems, suggesting a potential effect on T-cell turnover. This study explored relationships between MDR1 polymorphisms and phase 1 viral decay among 31 HIV-infected individuals initiating antiretroviral therapy. Position 3435 genotypes were CC in 7 (23%), CT in 14 (45%), and TT in 10 (32%). Position 2677 genotypes were GG in 8 (26%), GT in 18 (58%), and TT in 5 (16%). There was no significant relationship between allelic variants in either exon 26 or 21 and phase 1 or phase 2 viral decay, changes in lymphocyte subsets over time, or plasma trough ritonavir concentrations. It is concluded with 95% confidence that phase 1 viral decay differences between exon 26 TT and CC groups are unlikely to exceed 18%.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/AI-25765,
http://linkedlifedata.com/resource/pubmed/grant/AI-25879,
http://linkedlifedata.com/resource/pubmed/grant/AI-25915,
http://linkedlifedata.com/resource/pubmed/grant/AI-25919,
http://linkedlifedata.com/resource/pubmed/grant/AI-32770,
http://linkedlifedata.com/resource/pubmed/grant/AI-36219,
http://linkedlifedata.com/resource/pubmed/grant/AI-38855,
http://linkedlifedata.com/resource/pubmed/grant/AI-38858,
http://linkedlifedata.com/resource/pubmed/grant/AI-44748,
http://linkedlifedata.com/resource/pubmed/grant/AI-45356,
http://linkedlifedata.com/resource/pubmed/grant/AI-46339,
http://linkedlifedata.com/resource/pubmed/grant/CA-46934,
http://linkedlifedata.com/resource/pubmed/grant/GM-31304,
http://linkedlifedata.com/resource/pubmed/grant/RR-0080,
http://linkedlifedata.com/resource/pubmed/grant/RR0051
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Nov
|
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pubmed:issn |
1525-4135
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pubmed:author |
pubmed-author:BensonConstanceC,
pubmed-author:BoschRonald JRJ,
pubmed-author:ConnickElizabethE,
pubmed-author:HaasDavid WDW,
pubmed-author:KesslerHaroldH,
pubmed-author:KimRichard BRB,
pubmed-author:KuritzkesDanielD,
pubmed-author:LandayAlanA,
pubmed-author:LedermanMichael MMM,
pubmed-author:LiHaihongH,
pubmed-author:WilkinsonGrant RGR,
pubmed-author:WuHulinH
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|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
34
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
295-8
|
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pubmed:dateRevised |
2007-11-14
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|
pubmed:meshHeading |
pubmed-meshheading:14600574-Adult,
pubmed-meshheading:14600574-Alleles,
pubmed-meshheading:14600574-CD4 Lymphocyte Count,
pubmed-meshheading:14600574-CD4-Positive T-Lymphocytes,
pubmed-meshheading:14600574-Drug Therapy, Combination,
pubmed-meshheading:14600574-Female,
pubmed-meshheading:14600574-Genes, MDR,
pubmed-meshheading:14600574-HIV Infections,
pubmed-meshheading:14600574-HIV Protease Inhibitors,
pubmed-meshheading:14600574-HIV-1,
pubmed-meshheading:14600574-Humans,
pubmed-meshheading:14600574-Lamivudine,
pubmed-meshheading:14600574-Male,
pubmed-meshheading:14600574-Middle Aged,
pubmed-meshheading:14600574-P-Glycoprotein,
pubmed-meshheading:14600574-Polymorphism, Single Nucleotide,
pubmed-meshheading:14600574-RNA, Viral,
pubmed-meshheading:14600574-Retrospective Studies,
pubmed-meshheading:14600574-Ritonavir,
pubmed-meshheading:14600574-Zidovudine
|
|
pubmed:year |
2003
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|
pubmed:articleTitle |
MDR1 gene polymorphisms and phase 1 viral decay during HIV-1 infection: an adult AIDS Clinical Trials Group study.
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pubmed:affiliation |
Division of Infectious Diseases, Vanderbilt University School of Medicine, 345 24th Avenue, North, Suite 105, Nashville, TN 37212, USA. david.w.haas@vanderbilt.edu
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Multicenter Study,
Research Support, N.I.H., Extramural
|
