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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-11-5
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pubmed:abstractText |
Insulin peptide B:9-23 is a major autoantigen in type 1 diabetes that induces insulin autoantibodies and prevents diabetes in the NOD. However, immunization with peptide without adjuvant may be insufficient to reverse disease or induce long-term tolerance. Furthermore, recent experience has demonstrated the potential dangers of disease exacerbation or anaphylaxis with peptide immunotherapy.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclophosphamide,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/insulin B (9-23)
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0896-8411
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
213-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:14599846-Adoptive Transfer,
pubmed-meshheading:14599846-Animals,
pubmed-meshheading:14599846-Antibodies,
pubmed-meshheading:14599846-Antibodies, Monoclonal,
pubmed-meshheading:14599846-Antigens, CD4,
pubmed-meshheading:14599846-Autoantibodies,
pubmed-meshheading:14599846-Blood Glucose,
pubmed-meshheading:14599846-Cyclophosphamide,
pubmed-meshheading:14599846-Diabetes Mellitus, Type 1,
pubmed-meshheading:14599846-Female,
pubmed-meshheading:14599846-Insulin,
pubmed-meshheading:14599846-Insulin Antibodies,
pubmed-meshheading:14599846-Islets of Langerhans,
pubmed-meshheading:14599846-Mice,
pubmed-meshheading:14599846-Mice, Inbred NOD,
pubmed-meshheading:14599846-Mice, SCID,
pubmed-meshheading:14599846-Peptide Fragments,
pubmed-meshheading:14599846-Spleen,
pubmed-meshheading:14599846-Survival Analysis,
pubmed-meshheading:14599846-Vaccination
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pubmed:year |
2003
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pubmed:articleTitle |
Nondepleting anti-CD4 monoclonal antibody prevents diabetes and blocks induction of insulin autoantibodies following insulin peptide B:9-23 immunization in the NOD mouse.
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pubmed:affiliation |
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B140, Denver, CO 80262, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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