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pubmed-article:14598389pubmed:abstractTextK(+) (K) channels play a role in the proliferation of many cell types in normal cells and certain disease states. Several laboratories have studied K currents in cultured Schwann cells from models of the human diseases, neurofibromatosis type 1 (NF1) and neurofibromatosis type 2 (NF2). These diseases are characterized by the growth of Schwann cell tumors. In all cell culture NF models the K current properties differ in tumor-derived and normal Schwann cells. Depending on the model however, the type of K channel abnormality differs. K channels appear to play a role in the proliferation of Schwann cell cultures of these disease models, because a link has been established between K current blockade and the inhibition of Schwann cell proliferation in NF1 and NF2. Differences in the proliferation response of normal Schwann cells to K channel blockers suggest that in vitro regulation of proliferation in neoplastic and normal Schwann cells is complex.lld:pubmed
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pubmed-article:14598389pubmed:monthNovlld:pubmed
pubmed-article:14598389pubmed:issn1548-8969lld:pubmed
pubmed-article:14598389pubmed:authorpubmed-author:FieberLynne...lld:pubmed
pubmed-article:14598389pubmed:copyrightInfoCopyright 2003. Wiley-Liss, Inc.lld:pubmed
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pubmed-article:14598389pubmed:pagination76-83lld:pubmed
pubmed-article:14598389pubmed:dateRevised2009-10-5lld:pubmed
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pubmed-article:14598389pubmed:year2003lld:pubmed
pubmed-article:14598389pubmed:articleTitleVoltage-Gated ion currents of schwann cells in cell culture models of human neurofibromatosis.lld:pubmed
pubmed-article:14598389pubmed:affiliationDivision of Marine Biology and Fisheries, University of Miami Rosentiel School, Miami, Florida, 33149, USA. lfieber@rsmas.miami.edulld:pubmed
pubmed-article:14598389pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:14598389pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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