pubmed-article:14598389 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:14598389 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:14598389 | lifeskim:mentions | umls-concept:C0162678 | lld:lifeskim |
pubmed-article:14598389 | lifeskim:mentions | umls-concept:C0026339 | lld:lifeskim |
pubmed-article:14598389 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
pubmed-article:14598389 | lifeskim:mentions | umls-concept:C0036387 | lld:lifeskim |
pubmed-article:14598389 | lifeskim:mentions | umls-concept:C0007585 | lld:lifeskim |
pubmed-article:14598389 | lifeskim:mentions | umls-concept:C0162585 | lld:lifeskim |
pubmed-article:14598389 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:14598389 | pubmed:dateCreated | 2003-11-4 | lld:pubmed |
pubmed-article:14598389 | pubmed:abstractText | K(+) (K) channels play a role in the proliferation of many cell types in normal cells and certain disease states. Several laboratories have studied K currents in cultured Schwann cells from models of the human diseases, neurofibromatosis type 1 (NF1) and neurofibromatosis type 2 (NF2). These diseases are characterized by the growth of Schwann cell tumors. In all cell culture NF models the K current properties differ in tumor-derived and normal Schwann cells. Depending on the model however, the type of K channel abnormality differs. K channels appear to play a role in the proliferation of Schwann cell cultures of these disease models, because a link has been established between K current blockade and the inhibition of Schwann cell proliferation in NF1 and NF2. Differences in the proliferation response of normal Schwann cells to K channel blockers suggest that in vitro regulation of proliferation in neoplastic and normal Schwann cells is complex. | lld:pubmed |
pubmed-article:14598389 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14598389 | pubmed:language | eng | lld:pubmed |
pubmed-article:14598389 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14598389 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:14598389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14598389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14598389 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:14598389 | pubmed:month | Nov | lld:pubmed |
pubmed-article:14598389 | pubmed:issn | 1548-8969 | lld:pubmed |
pubmed-article:14598389 | pubmed:author | pubmed-author:FieberLynne... | lld:pubmed |
pubmed-article:14598389 | pubmed:copyrightInfo | Copyright 2003. Wiley-Liss, Inc. | lld:pubmed |
pubmed-article:14598389 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:14598389 | pubmed:day | 1 | lld:pubmed |
pubmed-article:14598389 | pubmed:volume | 300 | lld:pubmed |
pubmed-article:14598389 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:14598389 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:14598389 | pubmed:pagination | 76-83 | lld:pubmed |
pubmed-article:14598389 | pubmed:dateRevised | 2009-10-5 | lld:pubmed |
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pubmed-article:14598389 | pubmed:year | 2003 | lld:pubmed |
pubmed-article:14598389 | pubmed:articleTitle | Voltage-Gated ion currents of schwann cells in cell culture models of human neurofibromatosis. | lld:pubmed |
pubmed-article:14598389 | pubmed:affiliation | Division of Marine Biology and Fisheries, University of Miami Rosentiel School, Miami, Florida, 33149, USA. lfieber@rsmas.miami.edu | lld:pubmed |
pubmed-article:14598389 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:14598389 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:14598389 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
pubmed-article:14598389 | pubmed:publicationType | Review | lld:pubmed |