Linked Life Data

14598389

Source:http://linkedlifedata.com/resource/pubmed/id/14598389

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-11-4
pubmed:abstractText
K(+) (K) channels play a role in the proliferation of many cell types in normal cells and certain disease states. Several laboratories have studied K currents in cultured Schwann cells from models of the human diseases, neurofibromatosis type 1 (NF1) and neurofibromatosis type 2 (NF2). These diseases are characterized by the growth of Schwann cell tumors. In all cell culture NF models the K current properties differ in tumor-derived and normal Schwann cells. Depending on the model however, the type of K channel abnormality differs. K channels appear to play a role in the proliferation of Schwann cell cultures of these disease models, because a link has been established between K current blockade and the inhibition of Schwann cell proliferation in NF1 and NF2. Differences in the proliferation response of normal Schwann cells to K channel blockers suggest that in vitro regulation of proliferation in neoplastic and normal Schwann cells is complex.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1548-8969
pubmed:author
pubmed:copyrightInfo
Copyright 2003. Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
300
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
76-83
pubmed:dateRevised
2009-10-5
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Voltage-Gated ion currents of schwann cells in cell culture models of human neurofibromatosis.
pubmed:affiliation
Division of Marine Biology and Fisheries, University of Miami Rosentiel School, Miami, Florida, 33149, USA. lfieber@rsmas.miami.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Review