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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2003-11-4
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pubmed:abstractText |
Dose-dependent torsades de pointes has been shown to occur with dofetilide (Tikosyn) and sotalol HCl (Betapace AF); thus, detailed dosing and monitoring recommendations to minimize this risk are included in the product labeling for both drugs. Only dofetilide, however, has a mandated risk-management program that restricts distribution of the drug and requires prescriber education on the drug. We investigated whether this program improved adherence to dosing and monitoring recommendations for dofetilide as compared with sotalol.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1097-6744
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
146
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
894-901
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:14597941-Arrhythmias, Cardiac,
pubmed-meshheading:14597941-Dose-Response Relationship, Drug,
pubmed-meshheading:14597941-Drug Interactions,
pubmed-meshheading:14597941-Drug Monitoring,
pubmed-meshheading:14597941-Electrocardiography,
pubmed-meshheading:14597941-Female,
pubmed-meshheading:14597941-Guideline Adherence,
pubmed-meshheading:14597941-Humans,
pubmed-meshheading:14597941-Incidence,
pubmed-meshheading:14597941-Male,
pubmed-meshheading:14597941-Middle Aged,
pubmed-meshheading:14597941-North Carolina,
pubmed-meshheading:14597941-Phenethylamines,
pubmed-meshheading:14597941-Practice Guidelines as Topic,
pubmed-meshheading:14597941-Product Labeling,
pubmed-meshheading:14597941-Program Evaluation,
pubmed-meshheading:14597941-Risk Management,
pubmed-meshheading:14597941-Sotalol,
pubmed-meshheading:14597941-Sulfonamides,
pubmed-meshheading:14597941-Torsades de Pointes
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pubmed:year |
2003
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pubmed:articleTitle |
Evaluation of the dofetilide risk-management program.
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pubmed:affiliation |
Duke Center for Education and Research on Therapeutics and the Division of Cardiology, Duke Clinical Research Institute, Durham, NC 27715, USA. allen003@mc.duke.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Evaluation Studies
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