Linked Life Data

14597319

Source:http://linkedlifedata.com/resource/pubmed/id/14597319

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2003-11-4
pubmed:abstractText
Positron emission tomography with (18)F-fluorodeoxyglucose (FDG-PET) has been used to study neurodegenerative disease for the past two decades. This imaging method has conclusively demonstrated that dementing diseases are multifocal, rather than global, brain disorders and has shown that clinically similar dementias may have significantly different patterns of regional glucose metabolism. These observations have helped to focus pathological investigations and provided new insights into disease pathophysiology, yet the diagnostic potential of FDG-PET has not been fully exploited. Now that FDG-PET is becoming widely available to clinicians, it is timely to consider how to evaluate its utility in diagnosing dementing diseases. FDG-PET may be especially valuable in the clinical recognition of frontotemporal dementia (FTD). FTD causes a distinctive pattern of cerebral glucose hypometabolism, but can be difficult to distinguish clinically from more common disorders such as Alzheimer's disease and psychiatric disturbances. Currently available studies primarily evaluate metabolic changes in groups of patients and are inadequate to rely upon when evaluating individuals. Additional carefully designed clinical trials are needed to validate FDG-PET as a diagnostic biomarker.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0014-4886
pubmed:author
pubmed:issnType
Print
pubmed:volume
184 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S2-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Validating FDG-PET as a biomarker for frontotemporal dementia.
pubmed:affiliation
Department of Neurology and Institute of Gerontology, University of Michigan, Ann Arbor, MI, USA. nlfoster@umich.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Validation Studies