Linked Life Data

14596544

Source:http://linkedlifedata.com/resource/pubmed/id/14596544

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-11-4
pubmed:abstractText
Knowledge of epidemiological mechanisms and parameters underlying scrapie transmission in sheep flocks remains very limited at present. Here we introduce a method for fitting stochastic transmission models to outbreak data to estimate bounds on key transmission parameters. We apply this method to data describing an outbreak of scrapie in a closed flock of Romanov sheep. The main findings are that the relative infectiousness of infected animals in this outbreak becomes appreciable early into disease incubation and that the mean incubation period is less than 1.5 years. We also find that the data are consistent with a broad range of values for the basic reproduction number R0 and describe how the boundaries of this range depend on assumptions about the mean incubation period and the contribution to transmission of a long-lived environmental reservoir of infectivity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0950-2688
pubmed:author
pubmed:issnType
Print
pubmed:volume
131
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1015-22
pubmed:dateRevised
2010-5-17
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Dynamics of a scrapie outbreak in a flock of Romanov sheep--estimation of transmission parameters.
pubmed:affiliation
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Marys' Campus, Norfolk Place, London W2 1PG.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't