Linked Life Data

14595852

Source:http://linkedlifedata.com/resource/pubmed/id/14595852

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2003-11-3
pubmed:abstractText
The metabolic functions of NADP(+)-specific isocitrate dehydrogenase (ID2), which may participate in the production of NADPH and biosynthesis of fatty acids, are not yet clearly understood. Accordingly, the current study investigated the effect of oxalomalate, known as a competitive inhibitor of ID2 in vitro, on lipid metabolism and the cellular defense system in vivo. Male Sprague Dawley rats (3 weeks old) were divided into two groups, fed a pelletized AIN-76 semisynthetic diet for 8 weeks, and injected intraperioneally with either saline or oxalomalate (25 mg/kg BW) dissolved in saline every 2 days. Oxalomalate did not lower the body weight and adipose tissue weight significantly; however, it significantly lower the plasma leptin concentration (p < 0.000), plasma and hepatic triglyceride levels (p < 0.01, p < 0.05), and adipocyte lipoprotein lipase activity (p < 0.01) compared to the control group. Meanwhile, hepatic antioxidant enzyme activities, except for superoxide dismutase activity (p < 0.01), glutathione content, and thiobarbituric acid reactive substances levels were not significantly different between the groups. Therefore, the current data suggests that oxalomalate produces a triglyceride-lowering activity and play a possible inhibitory role in fat accumulation. Furthermore, it was not found to affect the most antioxidative enzyme activities, glutathione content, and thiobarbituric acid reactive substances levels in rats fed normal diet.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1095-6670
pubmed:author
pubmed:copyrightInfo
Copyright 2003 Wiley Periodicals, Inc. J Biochem Mol Toxicol 17:295-302, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.10092
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
295-302
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:14595852-Adipose Tissue, pubmed-meshheading:14595852-Alanine Transaminase, pubmed-meshheading:14595852-Animals, pubmed-meshheading:14595852-Aspartate Aminotransferases, pubmed-meshheading:14595852-Body Weight, pubmed-meshheading:14595852-Catalase, pubmed-meshheading:14595852-Glutathione, pubmed-meshheading:14595852-Injections, Intraperitoneal, pubmed-meshheading:14595852-Leptin, pubmed-meshheading:14595852-Lipoprotein Lipase, pubmed-meshheading:14595852-Liver, pubmed-meshheading:14595852-Male, pubmed-meshheading:14595852-Organ Size, pubmed-meshheading:14595852-Oxalates, pubmed-meshheading:14595852-Rats, pubmed-meshheading:14595852-Rats, Sprague-Dawley, pubmed-meshheading:14595852-Superoxide Dismutase, pubmed-meshheading:14595852-Thiobarbituric Acid Reactive Substances, pubmed-meshheading:14595852-Triglycerides
pubmed:year
2003
pubmed:articleTitle
Effect of oxalomalate on lipid metabolism and antioxidant defense system in rats.
pubmed:affiliation
Department of Food Science and Nutrition, Kyungpook National University, Daegu, 702-701, Republic of Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't