Source:http://linkedlifedata.com/resource/pubmed/id/14595650
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2003-11-3
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| pubmed:abstractText |
Growth hormone (GH) is neuroprotective, presumably through its actions on GH receptor-mediated pathways. Here, we examined the effects of GH using in vitro and in vivo assays of human immunodeficiency virus (HIV)-induced neuronal injury. Neuronal cultures were in assays of neurotoxicity induced by supernatants from HIV-1 tat-transfected monocytoid cells (Tat supernatant). GH treatment reduced neuronal death compared with untreated cultures (p < 0.001), which was blocked by a GH receptor antagonist, B2036. Tat supernatant-induced p53 expression in neurons was also reduced by GH treatment. Expression of both p53 and GH receptor were increased in brain tissue from HIV-infected persons compared with controls (p < 0.05). Mice receiving intrastriatal implants of Tat supernatant and treated with GH showed less neurobehavioral abnormalities together with reduced neuroinflammation and neuronal injury compared with untreated animals (p < 0.01). Three acquired immunodeficiency syndrome-defined patients with neurocognitive impairment were serially evaluated during daily GH treatment showing a sustained improvement in neuropsychological performance (p < 0.01). GH prevents neuronal death through its actions on neurons involving a p53-mediated pathway and also improved in vivo neurological function, indicating that GH may have a role in the treatment of HIV-induced neurodegeneration.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Conditioned,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, tat,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Somatotropin,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53,
http://linkedlifedata.com/resource/pubmed/chemical/tat Gene Products, Human...
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0364-5134
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
54
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
605-14
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:14595650-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:14595650-Animals,
pubmed-meshheading:14595650-Blotting, Western,
pubmed-meshheading:14595650-Brain,
pubmed-meshheading:14595650-Culture Media, Conditioned,
pubmed-meshheading:14595650-Gene Products, tat,
pubmed-meshheading:14595650-Growth Hormone,
pubmed-meshheading:14595650-HIV-1,
pubmed-meshheading:14595650-Humans,
pubmed-meshheading:14595650-In Situ Nick-End Labeling,
pubmed-meshheading:14595650-Mice,
pubmed-meshheading:14595650-Nerve Degeneration,
pubmed-meshheading:14595650-Neurons,
pubmed-meshheading:14595650-Neuropsychological Tests,
pubmed-meshheading:14595650-Receptors, Somatotropin,
pubmed-meshheading:14595650-Terminal Repeat Sequences,
pubmed-meshheading:14595650-Transfection,
pubmed-meshheading:14595650-Treatment Outcome,
pubmed-meshheading:14595650-Tumor Suppressor Protein p53,
pubmed-meshheading:14595650-U937 Cells,
pubmed-meshheading:14595650-tat Gene Products, Human Immunodeficiency Virus
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| pubmed:year |
2003
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| pubmed:articleTitle |
Growth hormone prevents human immunodeficiency virus-induced neuronal p53 expression.
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| pubmed:affiliation |
Department of Clinical Neurosciences, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|