Source:http://linkedlifedata.com/resource/pubmed/id/14594658
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2003-11-3
|
| pubmed:abstractText |
The aim of this study was to assess and compare the acute lung toxicities of intratracheally instilled hydrophobic relative to hydrophilic surface-coated titanium dioxide (TiO(2)) particles using a pulmonary bridging methodology. In addition, the results of these instillation studies were bridged with data previously generated from inhalation studies with hydrophilic, pigment-grade (base) TiO(2) particles, using the base, pigment-grade TiO(2) particles as the inhalation/instillation bridge material. To conduct toxicity comparisons, the surface coatings of base pigment-grade TiO(2) particles were made hydrophobic by application of triethoxyoctylsilane (OTES), a commercial product used in plastics applications. For the bioassay experimental design, rats were intratracheally instilled with 2 or 10 mg/kg of the following TiO(2) particle-types: (1) base (hydrophilic) TiO(2) particles; (2) TiO(2) with OTES surface coating; (3) base TiO(2) with Tween 80; or (4) OTES TiO(2) with Tween 80. Saline instilled rats served as controls. Following exposures, the lungs of sham- and TiO(2)-exposed rats were assessed both using bronchoalveolar lavage (BAL) biomarkers and by histopathology of lung tissue at 24 hours, 1 week, 1 month, and 3 months post exposure. The results demonstrated that only the base, high-dose (10 mg/kg) pigment-grade TiO(2) particles and those with particle-types containing Tween 80 produced a transient pulmonary inflammatory response, and this was reversible within 1 week postexposure. The authors conclude that the OTES hydrophobic coating on the pigment-grade TiO(2) particle does not cause significant pulmonary toxicity.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Coated Materials, Biocompatible,
http://linkedlifedata.com/resource/pubmed/chemical/Pigments, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/Polysorbates,
http://linkedlifedata.com/resource/pubmed/chemical/Silicones,
http://linkedlifedata.com/resource/pubmed/chemical/Titanium,
http://linkedlifedata.com/resource/pubmed/chemical/titanium dioxide
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0190-2148
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
593-606
|
| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:14594658-Animals,
pubmed-meshheading:14594658-Biological Markers,
pubmed-meshheading:14594658-Bronchoalveolar Lavage,
pubmed-meshheading:14594658-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:14594658-Coated Materials, Biocompatible,
pubmed-meshheading:14594658-Dose-Response Relationship, Drug,
pubmed-meshheading:14594658-Inhalation Exposure,
pubmed-meshheading:14594658-Intubation, Intratracheal,
pubmed-meshheading:14594658-Lung,
pubmed-meshheading:14594658-Male,
pubmed-meshheading:14594658-Pigments, Biological,
pubmed-meshheading:14594658-Polysorbates,
pubmed-meshheading:14594658-Rats,
pubmed-meshheading:14594658-Rats, Inbred Strains,
pubmed-meshheading:14594658-Recovery of Function,
pubmed-meshheading:14594658-Silicones,
pubmed-meshheading:14594658-Titanium,
pubmed-meshheading:14594658-Toxicity Tests, Acute
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Pulmonary toxicity studies in rats with triethoxyoctylsilane (OTES)-coated, pigment-grade titanium dioxide particles: bridging studies to predict inhalation hazard.
|
| pubmed:affiliation |
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA. david.b.warheit@usa.dupont.com
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|