Linked Life Data

14594128

Source:http://linkedlifedata.com/resource/pubmed/id/14594128

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-11-3
pubmed:abstractText
PBC is an old disease first described in 1851. It's predilection for women and its association with other autoimmune diseases suggests an immune based pathogenesis, but epidemiologic studies indicate that genetic and environmental factors play a role in the pathogenesis of PBC. The serologic hallmark for PBC, namely the antimitochondrial antibody, was first identified in 1965 and remains the most sensitive and specific hallmark for this disease. When first described, primary biliary cirrhosis was universally fatal but asymptomatic cases now represent more than 60% of cases diagnosed, less than half of whom will die of their liver disease. No specific therapy that effectively stops or reverses disease progression has been identified, thus it behoves investigators to aggressively pursue identification of the etiology of PBC.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1089-3261
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
735-40
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Primary biliary cirrhosis: historical perspective.
pubmed:affiliation
University of Toronto, Toronto, ON, #170 6B Fell, Toronto Western Hospital, 399 Bathurst St. Toronto, ON M5T 2S8, Canada. jenny.heathcote@utoronto.ca
pubmed:publicationType
Journal Article, Historical Article