Linked Life Data

14593478

Source:http://linkedlifedata.com/resource/pubmed/id/14593478

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2003-11-17
pubmed:abstractText
Hairy-related basic helix-loop-helix (bHLH) transcription factors are targets of Delta-Notch signaling and represent essential components for a number of cell fate decisions during vertebrate embryogenesis. Hey genes encode a subfamily of hairy-related proteins that have been implicated in processes like somitogenesis, blood vessel and heart development. We have identified and characterized hey genes in three teleost fish lineages using degenerate PCR and database searches. Phylogenetic analysis of Hey proteins suggests a complex pattern of evolution with high divergence of hey2 in Takifugu rubripes (Fugu, Japanese pufferfish) and possibly loss in the related Tetraodon nigroviridis (the freshwater pufferfish). In addition, duplication of hey1 in both pufferfishes, Fugu and Tetraodon, was observed. Conversely, zebrafish (Danio rerio) has the same complement of three hey genes as known from mammals. All three hey genes show much more restricted gene expression profiles in zebrafish when compared to mouse. Importantly, while all three murine Hey genes are expressed in overlapping patterns in the presomitic mesoderm (PSM) and somites, in zebrafish only hey1 shows PSM and somite expression in a highly dynamic fashion. Therefore, while overlapping expression might account for redundancy of hey function in higher vertebrates, this is unlikely to be the case in zebrafish. In deltaD (dlD) deficient after-eight zebrafish mutants, the dynamic expression of hey1 in the PSM is impaired and completely lost in newly formed somitomeres. Overexpression of dlD on the other hand results in the ectopic expression of hey1 in the axial mesoderm. Hence, hey1 represents a target of Delta-Notch signaling dynamically expressed during somite formation in zebrafish.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0949-944X
pubmed:author
pubmed:issnType
Print
pubmed:volume
213
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
541-53
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:14593478-Amino Acid Sequence, pubmed-meshheading:14593478-Animals, pubmed-meshheading:14593478-Basic Helix-Loop-Helix Transcription Factors, pubmed-meshheading:14593478-Biological Evolution, pubmed-meshheading:14593478-Gene Expression, pubmed-meshheading:14593478-Gene Expression Profiling, pubmed-meshheading:14593478-Helix-Loop-Helix Motifs, pubmed-meshheading:14593478-In Situ Hybridization, pubmed-meshheading:14593478-Mesoderm, pubmed-meshheading:14593478-Molecular Sequence Data, pubmed-meshheading:14593478-Nerve Tissue Proteins, pubmed-meshheading:14593478-Repressor Proteins, pubmed-meshheading:14593478-Signal Transduction, pubmed-meshheading:14593478-Somites, pubmed-meshheading:14593478-Takifugu, pubmed-meshheading:14593478-Tetraodontiformes, pubmed-meshheading:14593478-Transcription Factors, pubmed-meshheading:14593478-Zebrafish, pubmed-meshheading:14593478-Zebrafish Proteins
pubmed:year
2003
pubmed:articleTitle
Characterization of hey bHLH genes in teleost fish.
pubmed:affiliation
Department of Physiological Chemistry I, Biocenter, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany. winkler@biozentrum.uni-wuerzburg.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't