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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5646
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pubmed:dateCreated |
2003-10-31
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pubmed:abstractText |
In conjunction with histone modifications, DNA methylation plays critical roles in gene silencing through chromatin remodeling. Changes in DNA methylation perturb neuronal function, and mutations in a methyl-CpG-binding protein, MeCP2, are associated with Rett syndrome. We report that increased synthesis of brain-derived neurotrophic factor (BDNF) in neurons after depolarization correlates with a decrease in CpG methylation within the regulatory region of the Bdnf gene. Moreover, increased Bdnf transcription involves dissociation of the MeCP2-histone deacetylase-mSin3A repression complex from its promoter. Our findings suggest that DNA methylation-related chromatin remodeling is important for activity-dependent gene regulation that may be critical for neural plasticity.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Brain-Derived Neurotrophic Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Chromatin,
http://linkedlifedata.com/resource/pubmed/chemical/Chromosomal Proteins, Non-Histone,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP Response...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylases,
http://linkedlifedata.com/resource/pubmed/chemical/Mecp2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Methyl-CpG-Binding Protein 2,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SIN3A transcription factor,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
31
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pubmed:volume |
302
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
890-3
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:14593184-Animals,
pubmed-meshheading:14593184-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:14593184-Cells, Cultured,
pubmed-meshheading:14593184-Chromatin,
pubmed-meshheading:14593184-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:14593184-CpG Islands,
pubmed-meshheading:14593184-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:14593184-DNA Methylation,
pubmed-meshheading:14593184-DNA-Binding Proteins,
pubmed-meshheading:14593184-Gene Expression Regulation,
pubmed-meshheading:14593184-Gene Silencing,
pubmed-meshheading:14593184-Histone Deacetylases,
pubmed-meshheading:14593184-Methyl-CpG-Binding Protein 2,
pubmed-meshheading:14593184-Mice,
pubmed-meshheading:14593184-Mice, Inbred BALB C,
pubmed-meshheading:14593184-Models, Genetic,
pubmed-meshheading:14593184-Neuronal Plasticity,
pubmed-meshheading:14593184-Neurons,
pubmed-meshheading:14593184-Potassium Chloride,
pubmed-meshheading:14593184-Promoter Regions, Genetic,
pubmed-meshheading:14593184-Repressor Proteins,
pubmed-meshheading:14593184-Response Elements,
pubmed-meshheading:14593184-Transcription, Genetic,
pubmed-meshheading:14593184-Transcription Factors,
pubmed-meshheading:14593184-Transfection
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pubmed:year |
2003
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pubmed:articleTitle |
DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation.
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pubmed:affiliation |
Neuroscience Interdepartmental Program, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90095, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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