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rdf:type |
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lifeskim:mentions |
umls-concept:C0006560,
umls-concept:C0017262,
umls-concept:C0019612,
umls-concept:C0067533,
umls-concept:C0185117,
umls-concept:C0332461,
umls-concept:C0600388,
umls-concept:C1314939,
umls-concept:C1413716,
umls-concept:C1552644,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C1823153,
umls-concept:C2349976,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2004-1-6
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pubmed:abstractText |
It has been shown that plasma level of C-reactive protein (CRP) is an independent predictor for acute coronary syndromes and is associated with plaque weakening. However, the underlying mechanisms are not well understood. In this study, we investigated the effect of CRP on the expression of matrix metalloproteinase-1 (MMP-1) that has been implicated in plaque vulnerability by human U937 histiocytes and monocyte-derived macrophages.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
61-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:14592848-Arteriosclerosis,
pubmed-meshheading:14592848-C-Reactive Protein,
pubmed-meshheading:14592848-Enzyme Induction,
pubmed-meshheading:14592848-Extracellular Matrix,
pubmed-meshheading:14592848-Humans,
pubmed-meshheading:14592848-MAP Kinase Signaling System,
pubmed-meshheading:14592848-Macrophages,
pubmed-meshheading:14592848-Matrix Metalloproteinase 1,
pubmed-meshheading:14592848-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:14592848-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:14592848-Mitogen-Activated Protein Kinases,
pubmed-meshheading:14592848-Monocytes,
pubmed-meshheading:14592848-Phosphorylation,
pubmed-meshheading:14592848-Protein Processing, Post-Translational,
pubmed-meshheading:14592848-RNA, Messenger,
pubmed-meshheading:14592848-Receptors, IgG,
pubmed-meshheading:14592848-U937 Cells
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pubmed:year |
2004
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pubmed:articleTitle |
C-reactive protein stimulates MMP-1 expression in U937 histiocytes through Fc[gamma]RII and extracellular signal-regulated kinase pathway:: an implication of CRP involvement in plaque destabilization.
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pubmed:affiliation |
Ralph H. Johnson Veterans Affairs Medical Center and Division of Endocrinology, Diabetes and Medical Genetics, Department of Medicine, Medical University of South Carolina, 114 Doughty St, Charleston, SC 29403, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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