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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0021469,
umls-concept:C0023688,
umls-concept:C0079772,
umls-concept:C0085358,
umls-concept:C0205225,
umls-concept:C0221912,
umls-concept:C1171362,
umls-concept:C1332717,
umls-concept:C1334863,
umls-concept:C1413244,
umls-concept:C1415587,
umls-concept:C1416857,
umls-concept:C1515670,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
5
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pubmed:dateCreated |
2004-2-20
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pubmed:abstractText |
Primary cutaneous lymphomas constitute a spectrum of diseases characterized by a clonal accumulation of lymphocytes in the skin. Cutaneous T-cell lymphomas of the cytotoxic phenotype, including CD8+ and CD56+ lymphomas, are rare entities that have only been recently recognized and characterized. These lymphomas often show an aggressive clinical course. We investigated the expression of human leukocyte antigen G (HLA-G) and interleukin 10 (IL-10) in conjunction with expression of HLA-G killer-cell inhibitory receptor ligand immunoglobulin-like transcript 2 (ILT2) in 3 CD56+CD4+ and 4 CD8+ cutaneous T-cell lymphomas. HLA-G expression was detected in 2 of 3 lymphomas of the CD56+CD4+ type and in all lymphomas of CD8+ type. It is of note that CD56+CD4+ lymphomas displayed stronger HLA-G reactivity. The expression of IL-10 matched the expression of HLA-G. Together with the expression of IL-10, HLA-G might be one of the factors accounting for the evasion of immunosurveillance, thus contributing to aggressive phenotype of these lymphoma entities.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD56,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/HLA Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-G Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/LILRB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1796-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:14592815-Adult,
pubmed-meshheading:14592815-Aged,
pubmed-meshheading:14592815-Antigens, CD,
pubmed-meshheading:14592815-Antigens, CD56,
pubmed-meshheading:14592815-Antigens, CD8,
pubmed-meshheading:14592815-Female,
pubmed-meshheading:14592815-HLA Antigens,
pubmed-meshheading:14592815-HLA-G Antigens,
pubmed-meshheading:14592815-Histocompatibility Antigens Class I,
pubmed-meshheading:14592815-Humans,
pubmed-meshheading:14592815-Immunohistochemistry,
pubmed-meshheading:14592815-Interleukin-10,
pubmed-meshheading:14592815-Killer Cells, Natural,
pubmed-meshheading:14592815-Lymphoma,
pubmed-meshheading:14592815-Lymphoma, T-Cell,
pubmed-meshheading:14592815-Male,
pubmed-meshheading:14592815-Middle Aged,
pubmed-meshheading:14592815-Phenotype,
pubmed-meshheading:14592815-Receptors, Immunologic,
pubmed-meshheading:14592815-Skin Neoplasms
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pubmed:year |
2004
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pubmed:articleTitle |
Primary cutaneous CD8+ and CD56+ T-cell lymphomas express HLA-G and killer-cell inhibitory ligand, ILT2.
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pubmed:affiliation |
Department of Dermatology, University Hospital Zurich, Zurich, Switzerland. mirjana.urosevic@usz.ch
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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